Tumor-infiltrating B cells and T cells Working together to promote patient survival

被引：67

作者：

Nielsen, Julie S. ^{[1
,2
]}

Nelson, Brad H. ^{[1
,2
,3
]}

机构：

[1] BC Canc Agcy, Trev & Joyce Deeley Res Ctr, Victoria, BC, Canada

[2] Univ British Columbia, Dept Med Genet, Vancouver, BC, Canada

[3] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC, Canada

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 09期

关键词：

antigen-presenting cells; B cells; ovarian cancer; T cells; tumor-infiltrating lymphocytes; REVEALS;

D O I：

10.4161/onci.21650

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We recently reported a novel cooperative relationship between tumor-infiltrating B cells and CD8(+) T cells in ovarian cancer, leading to increased patient survival. Here, we discuss the mechanisms whereby B cells might enhance cellular immunity, including serving as antigen-presenting cells, organizing tertiary lymphoid structures and secreting polarizing cytokines. The enhancement of both B and T-cell responses may result in more potent and sustained antitumor immunity.

引用

页码：1623 / 1625

页数：3

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