An efficient synthesis of dopamine transporter tracer [18F]FECNT

被引：7
|
作者：
Murali, D. [1 ]
Barnhart, T. E. [1 ]
Vandehey, N. T. [1 ,2 ]
Christian, B. T. [1 ,2 ]
Nickles, R. J. [1 ]
Converse, A. K. [2 ]
Larson, J. A. [3 ]
Holden, J. E. [1 ]
Schneider, M. L. [3 ]
DeJesus, O. T. [1 ]
机构：
[1] Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
[2] Univ Wisconsin, Waisman Ctr, Madison, WI 53705 USA
[3] Univ Wisconsin, Dept Kinesiol, Madison, WI 53705 USA
来源：
APPLIED RADIATION AND ISOTOPES | 2013年 / 72卷
关键词：
F-18]FECNT; PET tracer; DAT ligands; Dopamine transporter; Positron emission tomography; PET; F-18-FECNT; REVERSAL; COCAINE; LIGAND; F-18;
D O I：
10.1016/j.apradiso.2012.10.010
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A simple synthesis of the dopamine transporter ligand [F-18]FECNT with high radiochemical yield and short synthesis time, suitable for routine production is reported. Reaction of 2 beta-carbomethoxy-3 beta-(4-chlorophenyl)nortropane with [F-18]2-fluoroethyl triflate ([F-18]FEtOTf) at room temperature for 4 min provided [F-18]FECNT in 84% decay corrected radiochemical yield. Since [F-18]FEtOTf was prepared from [F-18]2-fluoroethyl bromide that was isolated from its starting material, formation of unwanted side products and the amount of expensive precursor used could be greatly reduced. The overall radiochemical ;yields of [F-18]FECNT were 40% (n=29) and the total synthesis time was ca. 100 min. The average specific activity of [F-18]FECNT was 377.4 GBq/mu mol (10.2 Ci/mu mol). (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：128 / 132
页数：5
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