Acute Administration of Methyleugenol Impairs Hippocampus-Dependent Contextual Fear Memory and Increases Anxiety-like Behavior in Mice

被引:7
|
作者
Guo, Kai-Fei [3 ,4 ]
Dai, Man [3 ,4 ]
Liu, Yi-Miao [3 ,4 ]
Zhang, Ji-Chuan [5 ]
Chen, Yan-Mei [5 ]
Ye, Hui [6 ]
Li, Man-Bi [1 ]
Mao, Rong-Rong [2 ]
Cao, Jun [3 ,4 ]
机构
[1] Yunnan Inst Environm Sci, Kunming 650034, Yunnan, Peoples R China
[2] Kunming Med Univ, Sch Basic Med Sci, Dept Pathol & Pathophysiol, Kunming 650500, Yunnan, Peoples R China
[3] Yunnan Univ, Yunnan Key Lab Plant Reproduci Adapt & Evolutiona, Kunming 650504, Yunnan, Peoples R China
[4] Yunnan Univ, Sch Ecol & Environm Sci, Kunming 650504, Yunnan, Peoples R China
[5] Kunming Univ Sci & Technol, Med Sch, Dept Basic Med, Kunming 650500, Yunnan, Peoples R China
[6] Yunnan Univ, Sch Agr, Kunming 650504, Yunnan, Peoples R China
基金
中国国家自然科学基金;
关键词
methyleugenol; hippocampus; fear conditioning; synaptic plasticity; anxiety; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; METHYL-EUGENOL; RECEPTOR; DEPRESSION; PHOSPHORYLATION; INHIBITION; MECHANISM; DORSAL; CA1;
D O I
10.1021/acs.jafc.0c01863
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
Methyleugenol (ME) as a natural essential oil in many plant species is widely used in human food and beverage for its fragrance and possible beneficial health effects. Previous chronic or subacute studies in rodents show that ME mainly causes liver toxicity. However, whether and how acute ME affects the central nervous system still remain elusive. Here, we found that ME administrated into the hippocampus impaired the acquisition of hippocampus-dependent contextual fear memory in mice (ME vs control: repeated-measures two-way ANOVA, F-(5,F-70) = 2.937, p < 0.05; Fisher test, p < 0.05, respectively, 53 +/- 5.2% vs 73 +/- 7.6% during trial 4 and 46.8 +/- 6% vs 74.5 +/- 9.3% during trial 5). Meanwhile, acute ME impaired hippocampal CA1 long-term potentiation (LTP; ME vs control: independent t-test, p < 0.01, 110.6 +/- 1.8% vs 133.3 +/- 5.6%) while facilitated long-term depression (LTD; p < 0.01, 75.7 +/- 3.4% vs 88.6 +/- 1.7%) in mice brain slices and inducing a decrease in learning-dependent phosphorylation of Ser831 (ME vs control: independent t-test, p < 0.001, 0.87 +/- 0.03 vs 1.23 +/- 0.03) and Ser845 (p < 0.01, 0.42 +/- 0.07 vs 0.97 +/- 0.14) sites of excitatory glutamate AMPA receptor subunit 1 (GluA1) in the hippocampus, which may be the underlying mechanisms of impairment of hippocampus-dependent learning. In addition, intrahippocampal infusion of ME also increased anxiety-like behaviors in mice. These results suggested that acute ME impaired the hippocampus function at behavioral, cellular, and molecular levels, indicating the potential risks of ME on the central nervous system.
引用
收藏
页码:7490 / 7497
页数:8
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