Rosacea Pathogenesis

被引：116
|
作者：
Ahn, Christine S. [1 ]
Huang, William W. [1 ]
机构：
[1] Wake Forest Sch Med, Dept Dermatol, Med Ctr Blvd, Winston Salem, NC 27157 USA
来源：
DERMATOLOGIC CLINICS | 2018年 / 36卷 / 02期
关键词：
Kallikrein; Cathelicidin; Matrix metalloproteinase; Mast cells; Demodex; HUMAN DERMAL FIBROBLASTS; HELICOBACTER-PYLORI; PAPULOPUSTULAR ROSACEA; SKIN INFLAMMATION; EXPRESSION; DEMODEX; ULTRAVIOLET; PROTEINS; CELLS;
D O I：
10.1016/j.det.2017.11.001
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Rosacea is a chronic inflammatory skin disorder that is not fully understood but involves the complex interplay of genetic factors, immune dysregulation, neurovascular dysregulation, presence of microorganisms, and environmental factors. Increased activation of the immune system occurs through multiple stimuli, including increased levels of cathelicidin and kallikrein 5, Toll-like receptor 2, matrix metalloproteinases, and mast cells within the skin. Their effects are enhanced by the presence of microorganisms and external triggers, such as UV radiation.
引用
收藏
页码：81 / +
页数：7
相关论文
共 50 条
  • [21] Lupoid rosacea as a special form of rosacea. Review of pathogenesis and therapeutic options
    Vanstreels, L.
    Megahed, M.
    HAUTARZT, 2013, 64 (12): : 886 - 888
  • [22] The role of abnormal cutaneous steroidogenesis in the pathogenesis of rosacea
    Hong, J.
    Han, S.
    Kim, Y.
    Seo, E.
    Chung, J.
    Cho, S.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (09) : S270 - S270
  • [23] Current research and clinical trends in rosacea pathogenesis
    Hu, Xi-Min
    Li, Zhi-Xin
    Zhang, Dan-Yi
    Yang, Yi-Chao
    Zheng, Sheng-Yuan
    Zhang, Qi
    Wand, Xin-Xing
    Li, Ji
    Yang, Rong-Hua
    Xiong, Kun
    HELIYON, 2022, 8 (10)
  • [24] INVESTIGATING THE POTENTIAL ROLE OF MICROORGANISMS IN THE PATHOGENESIS OF ROSACEA
    Russell-Hallinan, A.
    Powell, F. C.
    Zouboulis, C. C.
    Lacey, N.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2012, 181 : S441 - S442
  • [25] Rosacea. Clinical features, pathogenesis and therapy
    Lehmann, R
    HAUTARZT, 2005, 56 (09): : 871 - 885
  • [26] INVOLVEMENT OF IMMUNE-MECHANISMS IN THE PATHOGENESIS OF ROSACEA
    MANNA, V
    MARKS, R
    HOLT, P
    BRITISH JOURNAL OF DERMATOLOGY, 1982, 107 (02) : 203 - 208
  • [27] Rosacea - contemporary views on the pathogenesis and therapy.
    Robak, Ewa
    Kulczycka, Lilianna
    POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ, 2010, 64 : 439 - 450
  • [28] Pathogenesis, clinical picture, and current therapy of rosacea
    Gonser, L. I.
    Gonser, C. E.
    Schaller, M.
    HAUTARZT, 2016, 67 (01): : 69 - 82
  • [29] Update on the pathogenesis and management of ocular rosacea: an interdisciplinary review
    Jabbehdari, Sayena
    Memar, Omeed Michael
    Caughlin, Benjamin
    Djalilian, Ali R.
    EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2021, 31 (01) : 22 - 33
  • [30] Rosacea: I. Etiology, pathogenesis, and subtype classification
    Crawford, GH
    Pelle, MT
    James, WD
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2004, 51 (03) : 327 - 341
12345