There is an increase in expression of the cytotoxic T-lymphocyte antigen-2 alpha gene during pregnancy

被引：6
|
作者：
Campo, MA [1 ]
Rice, EJ [1 ]
Kasik, JW [1 ]
机构：
[1] CASE WESTERN RESERVE UNIV,METROHLTH MED CTR,CLEVELAND,OH 44109
来源：
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1996年 / 174卷 / 05期
关键词：
uterus; placenta; pregnancy; cytotoxic T-lymphocyte-2 alpha;
D O I：
10.1016/S0002-9378(96)70614-2
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
OBJECTIVE: Our purpose was to identify genes that exhibit increased expression in the uterus during pregnancy. STUDY DESIGN: A differential screen was performed against a pregnant mouse uterus complementary deoxyribonucleic acid library by use of probes derived from pregnant and nonpregnant uterus. Multiple clones related to the cytotoxic T-lymphocyte antigen-2 alpha gene were isolated. RESULTS: Northern hybridization disclosed that message is present in both the gravid and nongravid uterus, but there is a substantial increase in expression during pregnancy. Expression is not found in a variety of other fetal and adult tissues evaluated (excluding placenta). CONCLUSION: The uterus (or cells present within the uterus) constitutes a major site of in vivo expression for the cytotoxic T-lymphocyte antigen-2 alpha gene, and expression of this gene is increased during pregnancy.
引用
收藏
页码：1605 / 1607
页数：3
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