Minireview: Regulation of Gap Junction Dynamics by Nuclear Hormone Receptors and Their Ligands

被引：29
|
作者：
Firestone, Gary L. [1 ]
Kapadia, Bhumika J.
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
来源：
MOLECULAR ENDOCRINOLOGY | 2012年 / 26卷 / 11期
关键词：
MESSENGER-RIBONUCLEIC-ACID; CELL-CELL JUNCTIONS; RETINOIC ACID; INTERCELLULAR COMMUNICATION; CONNEXIN43; GENE; TRANSCRIPTIONAL REGULATION; SUPRACHIASMATIC NUCLEUS; PROGESTERONE-RECEPTOR; INCREASED EXPRESSION; PROTEIN EXPRESSION;
D O I：
10.1210/me.2012-1065
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gap junctions are plasma membrane channels comprising connexin proteins that mediate intercellular permeability and communication. The presence, composition, and function of gap junctions can be regulated by diverse sets of physiological signals. Evidence from many hormone-responsive tissues has shown that connexin expression, modification, stability, and localization can be targeted by nuclear hormone receptors and their ligands through both transcriptional and nontranscriptional mechanisms. The focus of this review is to discuss molecular, cellular, and physiological studies that directly link receptor- and ligand-triggered signaling pathways to the regulation of gap junction dynamics. (Molecular Endocrinology 26: 1798-1807, 2012)
引用
收藏
页码：1798 / 1807
页数：10
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