Genetic Characterization of HIV Before Widespread Testing of HIV Vaccine Candidates at a Clinical Trial Site in Pretoria, South Africa

被引：0

作者：

Musyoki, Andrew ^{[1
]}

Mothapo, Khutso ^{[1
]}

Rakgole, Johnny ^{[1
]}

Lukhwareni, Azwidowi ^{[1
]}

Bessong, Pascal ^{[2
]}

Selabe, Gloria ^{[1
]}

Bredell, Helba ^{[3
]}

Williamson, Carolyn ^{[3
]}

Mphahlele, M. Jeffrey ^{[1
]}

机构：

[1] Univ Limpopo, Natl Hlth Lab Serv, Dept Virol, HIV & Hepatitis Res Unit, Pretoria, South Africa

[2] Univ Venda, Dept Microbiol, AIDS Virus Res Lab, Thohoyandou, South Africa

[3] Univ Cape Town, Natl Hlth Lab Serv, Div Med Virol, Inst Infect Dis & Mol Med, ZA-7925 Cape Town, South Africa

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 09期

基金：

英国医学研究理事会; 新加坡国家研究基金会;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; DIVERSITY; VPR; SEQUENCES; GAG; VIF;

D O I：

10.1089/aid.2011.0285

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied 123 samples from adult chronic HIV patients initiating HAART from various centers around a newly established clinical trial site in Pretoria. Each sample was sequenced in at least one structural gene (pol, gag, and env) or functional gene (vif, vpr, and vpu). A subset of 25 samples was subjected to near full-genome analysis. All samples were HIV-1 subtype C. Highly conserved-regions within the gene sequences were observed. Overall, the gag and vif sequences showed closer similarity followed by the env, vpr, pol, and vpu. The env gene was the most difficult to sequence, resulting in only 31 sequences from 40 samples; of these, 25 were predicted to be R5 coreceptor tropic, while 6 were X4 tropic. The study asserted the predominance of HIV-1 subtype C within the catchment population.

引用

页码：931 / 938

页数：8

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