Telaprevir decreases estimated glomerular filtration rate in HIV-hepatitis C virus coinfected patients

被引：2

作者：

Van den Eynde, Eva ^{[1
]}

Curto, Jordi ^{[1
]}

Ferrer, Elena ^{[1
]}

Imaz, Arkaitz ^{[1
]}

Saumoy, Maria ^{[1
]}

Di Yacovo, Silvana ^{[1
]}

Vila, Antonia ^{[1
]}

Podzamczer, Daniel ^{[1
]}

机构：

[1] Hosp Univ Bellvitge, Antigua Escuela Enfermeria, Infect Dis Serv, HIV Unit, Barcelona 08907, Spain

来源：

AIDS | 2015年 / 29卷 / 08期

关键词：

THERAPY;

D O I：

10.1097/QAD.0000000000000643

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated kidney function outcome in 24 chronic hepatitis C genotype 1 patients coinfected with HIV receiving telaprevir in a single tertiary care hospital in Spain. A statistically significant median (interquartile range) decrease in estimated glomerular filtration rate (eGFR, ml/min/1.73 m(2)) relative to baseline [93.6 (73.0-109.0)] was seen at weeks 4 [86.5 (34.0-112.0), P=0.014], 8 [90.0 (49.0-111.0), P=0.026] and 12 [89.5 (54.0-113.0), P=0.017]. These changes reversed after telaprevir discontinuation. Patients presenting an eGFR decrease had a higher risk of haematological toxicity.

引用

页码：977 / 979

页数：3

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