Telaprevir decreases estimated glomerular filtration rate in HIV-hepatitis C virus coinfected patients

被引：2
|
作者：
Van den Eynde, Eva [1 ]
Curto, Jordi [1 ]
Ferrer, Elena [1 ]
Imaz, Arkaitz [1 ]
Saumoy, Maria [1 ]
Di Yacovo, Silvana [1 ]
Vila, Antonia [1 ]
Podzamczer, Daniel [1 ]
机构：
[1] Hosp Univ Bellvitge, Antigua Escuela Enfermeria, Infect Dis Serv, HIV Unit, Barcelona 08907, Spain
来源：
AIDS | 2015年 / 29卷 / 08期
关键词：
THERAPY;
D O I：
10.1097/QAD.0000000000000643
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We investigated kidney function outcome in 24 chronic hepatitis C genotype 1 patients coinfected with HIV receiving telaprevir in a single tertiary care hospital in Spain. A statistically significant median (interquartile range) decrease in estimated glomerular filtration rate (eGFR, ml/min/1.73 m(2)) relative to baseline [93.6 (73.0-109.0)] was seen at weeks 4 [86.5 (34.0-112.0), P=0.014], 8 [90.0 (49.0-111.0), P=0.026] and 12 [89.5 (54.0-113.0), P=0.017]. These changes reversed after telaprevir discontinuation. Patients presenting an eGFR decrease had a higher risk of haematological toxicity.
引用
收藏
页码：977 / 979
页数：3
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