Substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA in lung cancer cells

被引：27

作者：

Cui, Lin ^{[1
]}

Wang, Meng ^{[1
]}

Sun, Bing ^{[2
]}

Ai, Shiyun ^{[3
]}

Wang, Shaocong ^{[1
]}

Zhang, Chun-yang ^{[1
]}

机构：

[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Shandong Prov Key Lab Clean Prod Fine Chem, Coll Chem Chem Engn & Mat Sci,Minist Educ,Key Lab, Jinan 250014, Shandong, Peoples R China

[2] China Univ Geosci Beijing, Sch Sci, Beijing 100183, Peoples R China

[3] Shandong Agr Univ, Coll Chem & Mat Sci, Tai An 271018, Shandong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 08期

基金：

中国国家自然科学基金;

关键词：

CARBON NANOTUBES; COPPER NANOPARTICLES; GOLD NANOPARTICLES; AMPLIFICATION; PEROXIDASE; NITROGEN; SIGNAL; NANOMATERIALS; CATALYSTS; ENZYME;

D O I：

10.1039/c8cc09688k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We develop a substrate-free and label-free electrocatalysis-assisted biosensor for sensitive detection of microRNA using the iron-embedded nitrogen-rich carbon nanotubes (FeCN) as the catalytic elements. This biosensor exhibits excellent selectivity and high sensitivity with a detection limit of 8.53 x 10(-16) M and a large dynamic range of 6 orders of magnitude. It can be further applied for accurate quantification of microRNA in lung cancer cells.

引用

页码：1172 / 1175

页数：4

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