Bi-directional regulation of emodin and quercetin on smooth muscle myosin of gizzard

被引：11
|
作者：
Zhang, HL [1 ]
Tang, ZY [1 ]
Yang, JX [1 ]
Zhang, Y [1 ]
Li, Y [1 ]
Lin, Y [1 ]
机构：
[1] Dalian Med Univ, Dept Pharmacol, Dalian 116027, Liaoning, Peoples R China
来源：
FEBS LETTERS | 2006年 / 580卷 / 02期
基金：
中国国家自然科学基金;
关键词：
emodin; quercetin; myosin Mg2+-ATPase activity; myosin phosphorylation; bidirectional regulation;
D O I：
10.1016/j.febslet.2005.12.041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This study is to reveal the characteristics of bidirectional regulation of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and quercetin on gizzard smooth muscle myosin. Our results indicate that: (a) emodin demonstrates stimulatory effects, and quercetin produces inhibitory effects on myosin phosphorylation and Mg2+-ATPase activities of Ca2+/calmodulin-dependent phosphorylated myosin in a dose-dependent manner; (b) a combination of emodin and quercetin enhances phosphorylation and Mg2+-ATPase activities for partially phosphorylated myosin and inhibits those activities for fully phosphorylated myosin; (c) 1-(5-Chloronaphthalene-1-sulfonyl)-1H2-hexahydro-1,4diazepine inhibits myosin phosphorylation in the presence of emodin and/or quercetin. A combination of emodin and quercetin indicates its potential for modulating gastric-intestinal smooth muscle. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：469 / 473
页数：5
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