A fluorescence-Raman dual-imaging platform based on complexes of conjugated polymers and carbon nanotubes

被引：15
|
作者：
Liu, Yun [1 ,2 ]
Huang, Jun [1 ,2 ]
Sun, Min-Jie [3 ]
Yu, Ji-Cheng [1 ,2 ]
Chen, Yu-Lei [1 ,2 ]
Zhang, Yu-Qi [1 ,2 ]
Jiang, Shao-Jun [4 ,5 ]
Shen, Qun-Dong [1 ,2 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Nanjing 210093, Jiangsu, Peoples R China
[2] Nanjing Univ, Sch Chem & Chem Engn, Key Lab Mesoscop Chem MOE, Nanjing 210093, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Peoples R China
[4] Jinling Hosp, Dept Pathol, Nanjing 210002, Jiangsu, Peoples R China
[5] Jinling Hosp, Lab Elect Microscopy, Nanjing 210002, Jiangsu, Peoples R China
来源：
NANOSCALE | 2014年 / 6卷 / 03期
基金：
中国国家自然科学基金;
关键词：
CHEMICAL SENSORS; DRUG DESIGN; LIVE CELLS; HELA-CELLS; DELIVERY; POLYELECTROLYTES; DNA; NANOPARTICLES; TRANSLOCATION; SPECTROSCOPY;
D O I：
10.1039/c3nr04430k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The present study describes a flexible nanoplatform based on electrostatic assembly of conjugated polyelectrolytes (CPEs) and carboxylated multi-walled carbon nanotubes (cMWNTs). It is demonstrated that the obtained nanocomposites inherit intrinsic optical properties of CPEs and characteristic Raman vibration modes of MWNTs, providing a fluorescence-Raman dual-imaging method for intracellular tracking and locating of MWNTs. We suggest that the cellular internalization of the CPE-cMWNT nanocomposites is a surface charge-dependent process. The strengths of this nanoplatform include satisfying biocompatibility, enhanced protein-repellent property, and ease of implementation, making it available for both in vitro and in vivo applications.
引用
收藏
页码：1480 / 1489
页数：10
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