Cerebral perfusion alterations in patients with trigeminal neuralgia as measured by pseudo-continuous arterial spin labeling

被引：1
|
作者：
Zhou, Qianling [1 ,2 ]
Li, Meng [2 ]
Fan, Qisen [3 ]
Chen, Feng [2 ]
Jiang, Guihua [2 ]
Wang, Tianyue [2 ]
He, Qinmeng [2 ]
Fu, Shishun [2 ]
Yin, Yi [2 ]
Lin, Jinzhi [4 ]
Yan, Jianhao [1 ,2 ]
机构：
[1] Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China
[2] Guangdong Second Prov Gen Hosp, Dept Med Imaging, Guangzhou, Peoples R China
[3] Guangzhou Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Guangzhou, Peoples R China
[4] Guangdong Second Prov Gen Hosp, Dept Neurosurg, Guangzhou, Peoples R China
来源：
FRONTIERS IN NEUROSCIENCE | 2022年 / 16卷
关键词：
trigeminal neuralgia; chronic pain; arterial spin labeling; cerebral blood flow; functional MRI; brain; DORSOLATERAL PREFRONTAL CORTEX; LOW-BACK-PAIN; FUNCTIONAL CONNECTIVITY; PREVALENCE; SYSTEM; IMPACT;
D O I：
10.3389/fnins.2022.1065411
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
BackgroundAccumulating evidence suggests that trigeminal neuralgia (TN) causes structural and functional alterations in the brain. However, only a few studies have focused on cerebral blood flow (CBF) changes in patients with TN. This study aimed to explore whether altered cerebral perfusion patterns exist in patients with TN and investigate the relationship between abnormal regional CBF (rCBF) and clinical characteristics of TN. Materials and methodsThis study included 28 patients with TN and 30 age- and sex-matched healthy controls (HCs) who underwent perfusion functional MRI (fMRI) of the brain using pseudo-continuous arterial spin labeling (pCASL) in the resting state. The regions of significantly altered CBF in patients with TN were detected using group comparison analyses. Then, the relationships between the clinical characteristics and abnormal rCBF were further investigated. ResultsCompared to the control group, patients with TN exhibited increased rCBF, primarily in the thalamus, middle frontal gyrus (MFG), and left insula. Furthermore, the CBF values of the thalamus were negatively correlated with the pain intensity of TN and positively correlated with pain duration in patients with TN. ConclusionPrimary alterations in rCBF in patients with TN occurred in different brain regions related to pain, which are involved in cognitive-affective interaction, pain perception, and pain modulation. These results indicate that non-invasive resting cerebral perfusion imaging may contribute complementary information to further understanding the neuropathological mechanism underlying TN.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] Robust estimation of quantitative perfusion from multi-phase pseudo-continuous arterial spin labeling
    Msayib, Y.
    Craig, M.
    Simard, M. A.
    Larkin, J. R.
    Shin, D. D.
    Liu, T. T.
    Sibson, N. R.
    Okell, T. W.
    Chappell, M. A.
    MAGNETIC RESONANCE IN MEDICINE, 2020, 83 (03) : 815 - 829
  • [22] Acoustic noise reduction in pseudo-continuous arterial spin labeling (pCASL)
    van der Meer, Johan N.
    Heijtel, Dennis F. R.
    van Hest, Guus
    Plattel, Geert-Jan
    van Osch, Matthijs J. P.
    van Someren, Eus J. W.
    vanBavel, Ed T.
    Nederveen, Aart J.
    MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE, 2014, 27 (03) : 269 - 276
  • [23] Pseudo-continuous arterial spin labeling imaging of cerebral blood perfusion asymmetry in drug-naive patients with first-episode major depression
    Chen, Guangdong
    Bian, Haiman
    Jiang, Deguo
    Cui, Mingwei
    Ji, Shengzhang
    Liu, Mei
    Lang, Xu
    Zhuo, Chuanjun
    BIOMEDICAL REPORTS, 2016, 5 (06) : 675 - 680
  • [24] Designing and comparing optimized pseudo-continuous Arterial Spin Labeling protocols for measurement of cerebral blood flow
    Woods, Joseph G.
    Chappell, Michael A.
    Okell, Thomas W.
    NEUROIMAGE, 2020, 223
  • [25] Localised increase in regional cerebral perfusion in patients with visual snow syndrome: a pseudo-continuous arterial spin labelling study
    Puledda, Francesca
    Schankin, Christoph J.
    O'Daly, Owen
    Ffytche, Dominic
    Eren, Ozan
    Karsan, Nazia
    Williams, Steve C. R.
    Zelaya, Fernando
    Goadsby, Peter J.
    JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2021, 92 (09): : 918 - 926
  • [26] Optimization of adiabatic pulses for pulsed arterial spin labeling at 7 tesla: Comparison with pseudo-continuous arterial spin labeling
    Wang, Kai
    Shao, Xingfeng
    Yan, Lirong
    Ma, Samantha J.
    Jin, Jin
    Wang, Danny J. J.
    MAGNETIC RESONANCE IN MEDICINE, 2021, 85 (06) : 3227 - 3240
  • [27] Spatial-temporal perfusion patterns of the human liver assessed by pseudo-continuous arterial spin labeling MRI
    Martirosian, Petros
    Pohmann, Rolf
    Schraml, Christina
    Schwartz, Martin
    Kuestner, Thomas
    Schwenzer, Nina Franziska
    Scheffler, Klaus
    Nikolaou, Konstantin
    Schick, Fritz
    ZEITSCHRIFT FUR MEDIZINISCHE PHYSIK, 2019, 29 (02): : 173 - 183
  • [28] In vivo visualization of the PICA perfusion territory with super-selective pseudo-continuous arterial spin labeling MRI
    Hartkamp, Nolan S.
    De Cocker, Laurens J.
    Helle, Michael
    van Osch, Matthias J. P.
    Kappelle, L. Jaap
    Bokkers, Reinoud P. H.
    Hendrikse, Jeroen
    NEUROIMAGE, 2013, 83 : 58 - 65
  • [29] Pseudo-continuous arterial spin labeling MRI study of patients with obsessive-compulsive disorder
    Ota, Miho
    Kanie, Ayako
    Kobayashi, Yuki
    Nakajima, Aiichiro
    Sato, Noriko
    Horikoshi, Masaru
    PSYCHIATRY RESEARCH-NEUROIMAGING, 2020, 303
  • [30] Estimation of Tagging Efficiency in Pseudo-Continuous Arterial Spin Labeling (pCASL) MRI
    Jen, M.
    Yan, F.
    Tseng, Y.
    Lin, C.
    Chen, C.
    Liu, H.
    MEDICAL PHYSICS, 2015, 42 (06) : 3256 - 3257
12345