Virological, Serological, and Antiviral Studies in an Imported Human Case of Avian Influenza A(H7N9) Virus in Taiwan

被引：38

作者：

Lin, Pi-Han ^{[1
]}

Chao, Tai-Ling ^{[1
]}

Kuo, Shuenn-Wen ^{[2
]}

Wang, Jann-Tay ^{[3
]}

Hung, Chien-Ching ^{[3
]}

Lin, Huan-Chun ^{[1
]}

Yang, Zong-Yu ^{[1
]}

Ho, Shu-Yuan ^{[4
]}

Chang, Chun-Kai ^{[1
]}

Huang, Ming-Siang ^{[1
]}

Chen, Hui-Hou ^{[4
]}

Chen, Yee-Chun ^{[3
]}

Lai, Hong-Shiee ^{[2
]}

Chang, Sui-Yuan ^{[1
,4
]}

Chang, Shan-Chwen ^{[3
]}

Yang, Pan-Chyr ^{[3
]}

机构：

[1] Natl Taiwan Univ, Coll Med, Dept Clin Lab Sci & Med Biotechnol, Taipei 10764, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Surg, Taipei 100, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 100, Taiwan

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 02期

关键词：

H7N9; oseltamivir; resistance; A H7N9 VIRUS; RESISTANCE; INFECTION; H5N1;

D O I：

10.1093/cid/cit638

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe the clinical course and virological characteristics of the first H7N9 influenza case in a Taiwanese patient; this patient had detectable viruses in the airway for 2 weeks, during which time an oseltamivir resistance-associated R292K mutation rapidly emerged. Anti-H7N9 antibody was detected 21 days after onset of symptoms, when H7N9 viral load declined significantly.

引用

页码：242 / 246

页数：5

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