A Ratiometric Fluorescent Probe for Cysteine and Homocysteine Displaying a Large Emission Shift

被引：297
|
作者：
Lin, Weiying [1 ]
Long, Lingliang [1 ]
Yuan, Lin [1 ]
Cao, Zengmei [1 ]
Chen, Bingbing [1 ]
Tan, Wen [1 ]
机构：
[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 24期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1021/ol802436j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-(1H-phenanthro[9,10-d]imidazol-2-yl)benzaldehyde 1 was rationally designed as a novel ratiometric fluorescent probe for cysteine and homocysteine. Upon addition of cysteine or homocysteine, notably, the probe displayed a very large (125 nm) hypsochromic shift in emission due to switching off intramolecular charge transfer. This large emission wavelength shift may allow probe 1 to be employed for quantitatively detecting Cys/Hcy.
引用
收藏
页码：5577 / 5580
页数：4
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