Highly Specific Enrichment of Glycopeptides Using Boronic Acid-Functionalized Mesoporous Silica

被引：284

作者：

Xu, Yawei ^{[1
,2
,4
]}

Wu, Zhangxiong ^{[1
,3
]}

Zhang, Lijuan ^{[1
,2
]}

Lu, Haojie ^{[1
,2
]}

Yang, Pengyuan ^{[1
,2
]}

Webley, Paul A. ^{[4
]}

Zhao, Dongyuan ^{[1
,3
,4
]}

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China

[3] Fudan Univ, Shanghai Key Lab Mol Catalysis & Innovat Mat, Shanghai 200433, Peoples R China

[4] Monash Univ, Dept Chem Engn, Clayton, Vic 3800, Australia

来源：

ANALYTICAL CHEMISTRY | 2009年 / 81卷 / 01期

基金：

中国国家自然科学基金;

关键词：

MASS-SPECTROMETRY; LINKED OLIGOSACCHARIDES; POROUS MATERIALS; CHROMATOGRAPHY; GLYCOPROTEOMICS; IDENTIFICATION; GLYCOSYLATION; ADSORPTION; MONOLAYERS; PROTEINS;

D O I：

10.1021/ac801912t

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel boronic acid functionalized mesoporous silica, which holds the attractive features of high surface area and large accessible porosity, was developed to enrich glycopeptides. This is the first time that mesoporous material has been introduced into glycoproteome. In comparison to direct (traditional) analysis, this novel method enabled 2 orders of magnitude improvement in the detection limit of glycopeptides. The unbiased nature of organo-boronic acid groups also made this method applicable to all kinds of glycopeptides regardless of their sizes, structures, and hydrophilicities.

引用

页码：503 / 508

页数：6

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