Ionic Channels as Potential Therapeutic Targets for Erectile Dysfunction: A Review

被引：5

作者：

Diniz, Anderson Fellyp Avelino ^{[1
]}

Ferreira, Rafael Carlos ^{[1
]}

de Souza, Iara Leao Luna ^{[2
]}

da Silva, Bagnolia Araujo ^{[1
]}

机构：

[1] Univ Fed Paraiba, Programa Posgrad Prod Nat & Sintet Bioat, Joao Pessoa, Paraiba, Brazil

[2] Univ Estadual Roraima, Dept Ciencias Biol & Saude, Boa Vista, Parana, Brazil

来源：

FRONTIERS IN PHARMACOLOGY | 2020年 / 11卷

关键词：

canalopathies; erectile dysfunction; Ca2+-activated K(+)channels; KCNQ-encoded voltage-dependent K(+)channels; transient receptor potential channels; calcium-activated chloride channels; CA2+-ACTIVATED K+ CHANNELS; KCNQ POTASSIUM CHANNELS; CAVERNOSUM SMOOTH-MUSCLE; CORPUS CAVERNOSUM; KV7; CHANNELS; METABOLIC SYNDROME; SMALL-CONDUCTANCE; K(V)7 CHANNELS; BKCA CHANNEL; ENDOTHELIAL DYSFUNCTION;

D O I：

10.3389/fphar.2020.01120

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Erectile dysfunction (ED) is a prevalent condition, especially in men over 40 years old, characterized by the inability to obtain and/or maintain penile erection sufficient for satisfactory sexual intercourse. Several psychological and/or organic factors are involved in the etiopathogenesis of ED. In this context, we gathered evidence of the involvement of Large-conductance, Ca2+-activated K(+)channels (BKCa), Small-conductance, Ca2+-activated K(+)channels (SKCa), KCNQ-encoded voltage-dependent K(+)channels (K(V)7), Transient Receptor Potential channels (TRP), and Calcium-activated Chloride channels (CaCC) dysfunctions on ED. In addition, the use of modulating agents of these channels are involved in relaxation of the cavernous smooth muscle cell and, consequent penile erection, suggesting that these channels are promising therapeutic targets for the treatment of erectile dysfunction.

引用

页数：13

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