Ring Opening of Pyrrolinium Ions Enabled Regioselective Synthesis of 4-Alkyl N-Arylpyrazoles

被引：2
|
作者：
Dwari, Soumita [1 ]
Nath, Partha Partim [1 ]
Jana, Chandan K. [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 18期
关键词：
ONE-POT SYNTHESIS; 1,3,5-TRISUBSTITUTED PYRAZOLINES; HANTZSCH 1,4-DIHYDROPYRIDINES; POLYSUBSTITUTED PYRAZOLES; OXIDATIVE AROMATIZATION; SUBSTITUTED PYRAZOLES; RECEPTOR; LIGANDS; CYCLOCONDENSATION; INHIBITORS;
D O I：
10.1021/acs.joc.2c00727
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented method for the regioselective synthesis of 1,3-diaryl 4-alkyl pyrazoles has been reported. A wide variety of 1,3-diaryl 4-alkyl pyrazoles were synthesized as a single regioisomer via a ring-opening cyclization reaction of unsaturated pyrrolinium ions in the presence of arylhydrazines. This method avoids using additional alkylation steps and hazardous oxidants that generally are essential for the synthesis of 4-alkyl N-arylpyrazoles.
引用
收藏
页码：11947 / 11957
页数：11
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