A New Antimalarial Aporphine Alkaloid from the Leaves of Amoora cucullata

被引：0

作者：

Chumkaew, Parinuch ^{[1
]}

Srisawat, Theera ^{[2
]}

机构：

[1] Prince Songkla Univ, Fac Sci & Ind Technol, Surat Thani Campus, Surat Thani 84000, Thailand

[2] Prince Songkla Univ, Fac Innovat Agr & Fisheries, Estab Project, Surat Thani Campus, Surat Thani 84000, Thailand

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2022年 / 58卷 / 06期

关键词：

Amoora cucullata; Meliaceae; aporphine; antimalarial activity; FRUITS; LIMONOIDS; ROOTS;

D O I：

10.1007/s10600-022-03875-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new aporphine alkaloid, amocurine F (1), along with five known compounds (2-6), was isolated from the leaves of Amoora cucullata. Their structures were elucidated using spectroscopic methods, including extensive 1D and 2D NMR techniques. All the isolated compounds were evaluated for antimalarial activity against Plasmodium falciparum. Compounds 1 and 2 exhibited the most potent activity against the K1 strain, with IC50 values of 1.84 and 3.52 mu M, respectively.

引用

页码：1085 / 1088

页数：4

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