Copper-Catalyzed Cascade Phosphorylation Initiated Radical Cyclization: Access to 2-Phosphorylated Pyrrolo[1,2-a]indole

被引：62
|
作者：
Zhang, Honglin [1 ]
Li, Weipeng [1 ]
Zhu, Chengjian [1 ,2 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Coordinat Chem, Jiangsu Key Lab Adv Organ Mat, Nanjing 210093, Jiangsu, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 04期
基金：
中国国家自然科学基金;
关键词：
CARBON-PHOSPHORUS FUNCTIONALIZATION; OXIDATIVE CYCLIZATION; BOND; DERIVATIVES; ALKENES; 2-ISOCYANOBIPHENYLS; ACTIVATION; INHIBITORS; OXIDES;
D O I：
10.1021/acs.joc.6b02673
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed tandem radical cyclization of 1-(3-phenylprop-2-yn-1-yl)-1H-indole with diphenylphosphine oxides was developed. CP bond formation was achieved coupled with C(sp(2))H functionalization. It provided an access to construct the pyrrolo[1,2-a]indole motif and a series of 2-phosphinoyl-9H-pyrrolo[1,2-a]indoles.
引用
收藏
页码：2199 / 2204
页数：6
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