The PNPLA3 SNP rs738409:G allele is associated with increased liver disease-associated mortality but reduced overall mortality in a population-based cohort

被引:35
|
作者
Meffert, Peter J. [1 ]
Repp, Katja D. [1 ]
Voelzke, Henry [1 ]
Weiss, F. Ulrich [2 ]
Homuth, Georg [3 ]
Kuhn, Jens P. [4 ]
Lerch, Markus M. [2 ]
Aghdassi, Ali A. [2 ]
机构
[1] Univ Med Greifswald, Inst Community Med, Greifswald, Germany
[2] Univ Med Greifswald, Dept Med A, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany
[3] Univ Med Greifswald, Inst Genet & Funct Genom, Greifswald, Germany
[4] Univ Med Greifswald, Inst Radiol, Greifswald, Germany
关键词
HEALTH;
D O I
10.1016/j.jhep.2017.11.038
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:858 / 860
页数:4
相关论文
共 50 条
  • [21] Epidemiological Study on the Interaction between the PNPLA3 (rs738409) and Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease
    Sato, Satoshi
    Iino, Chikara
    Sasada, Takafumi
    Soma, Go
    Furusawa, Keisuke
    Yoshida, Kenta
    Sawada, Kaori
    Mikami, Tatsuya
    Nakaji, Shigeyuki
    Sakuraba, Hirotake
    Fukuda, Shinsaku
    GENES, 2024, 15 (09)
  • [22] The PNPLA3 rs738409 G-Allele Associates with Reduced Fasting Serum Triglyceride and Serum Cholesterol in Danes with Impaired Glucose Regulation
    Krarup, Nikolaj Thure
    Grarup, Niels
    Banasik, Karina
    Friedrichsen, Martin
    Faerch, Kristine
    Sandholt, Camilla Helene
    Jorgensen, Torben
    Poulsen, Pernille
    Witte, Daniel Rinse
    Vaag, Allan
    Sorensen, Thorkild
    Pedersen, Oluf
    Hansen, Torben
    PLOS ONE, 2012, 7 (07):
  • [23] PNPLA3 (rs738409 C>G) is a common risk variant associated with hepatocellular carcinoma in alcoholic cirrhosis
    Trepo, Eric
    Guyot, Erwan
    Ganne-Carrie, Nathalie
    Degre, Delphine
    Gustot, Thierry
    Franchimont, Denis
    Sutton, Angela
    Nahon, Pierre
    Moreno, Christophe
    HEPATOLOGY, 2012, 55 (04) : 1307 - 1308
  • [24] PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study
    Angeles Jimenez-Sousa, Maria
    Zaida Gomez-Moreno, Ana
    Pineda-Tenor, Daniel
    Jose Sanchez-Ruano, Juan
    Fernandez-Rodriguez, Amanda
    Artaza-Varasa, Tomas
    Gomez-Sanz, Alicia
    Martin-Vicente, Maria
    Vazquez-Moron, Sonia
    Resino, Salvador
    JOURNAL OF CLINICAL VIROLOGY, 2018, 103 : 71 - 74
  • [25] Association of PNPLA3 rs738409 G/C gene polymorphism with nonalcoholic fatty liver disease in children: a meta-analysis
    Tang, Shan
    Zhang, Jing
    Mei, Ting Ting
    Guo, Hai Qing
    Wei, Xin Huan
    Zhang, Wen Yan
    Liu, Ya Li
    Liang, Shan
    Fan, Zuo Peng
    Xia, Li
    Lin, Wei
    Liu, Yi Rong
    Qiu, Li Xia
    Yu, Hai Bin
    BMC MEDICAL GENETICS, 2020, 21 (01)
  • [26] Association of PNPLA3 rs738409 C > G and rs2896019 T > G Polymorphisms with Nonalcoholic Fatty Liver Disease in a Turkish Population from Adıyaman Province
    Bayram, Suleyman
    Ulger, Yakup
    GENETIC TESTING AND MOLECULAR BIOMARKERS, 2025, 29 (03) : 63 - 73
  • [27] PNPLA3 RS738409 IS SIGNIFICANTLY AND INDEPENDENTLY ASSOCIATED WITH HISTOLOGICAL PROGRESSION AND REGRESSION IN MASLD: A LARGE PAIRED AND PROSPECTIVE LIVER BIOPSY STUDY
    Vilar-Gomez, Eduardo
    Yates, Katherine
    Kleiner, David
    Behling, Cynthia
    Cummings, Oscar
    Wilson, Laura
    Liang, Tiebing
    Jarasvaraparn, Chaowapong
    Loomba, Rohit
    Schwimmer, Jeffrey
    Sanyal, Arun
    Hoofnagle, Jay
    Chalasani, Naga
    HEPATOLOGY, 2024, 80 : S861 - S862
  • [28] Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study
    Julia Köpp
    Steffen Fleßa
    Wolfgang Lieb
    Marcello Ricardo Paulista Markus
    Alexander Teumer
    Georg Homuth
    Henri Wallaschofski
    Paul Marschall
    Henry Völzke
    Sebastian Edgar Baumeister
    BMC Health Services Research, 16
  • [29] THE PRESENCE OF A PNPLA3 (RS738409) SINGLE NUCLEOTIDE POLYMORPHISM (SNP) IS NOT ASSOCIATED WITH INCREASED RISK FOR FIBROSIS, PORTAL HYPERTENSION, AND HEPATIC STEATOSIS IN HIV/HCV-COINFECTED PATIENTS
    Scheiner, B.
    Mandorfer, M.
    Schwabl, P.
    Payer, B. A.
    Aichelburg, M. C.
    Grabmeier-Pfistershammer, K.
    Staettermayer, A.
    Ferenci, P.
    Trauner, M.
    Peck-Radosavljevic, M.
    Reiberger, T.
    JOURNAL OF HEPATOLOGY, 2015, 62 : S593 - S593
  • [30] Association of PNPLA3 rs738409 and TM6SF2 rs58542926 with health services utilization in a population-based study
    Koepp, Julia
    Flessa, Steffen
    Lieb, Wolfgang
    Markus, Marcello Ricardo Paulista
    Teumer, Alexander
    Homuth, Georg
    Wallaschofski, Henri
    Marschall, Paul
    Voelzke, Henry
    Baumeister, Sebastian Edgar
    BMC HEALTH SERVICES RESEARCH, 2016, 16