Multiple myeloma preparative regimens for high-dose therapy and autologous transplantation: what's new?

被引：0
|
作者：
Aljitawi, Omar S. [1 ]
McGuirk, Joseph P. [1 ]
机构：
[1] Univ Kansas, Med Ctr, Blood & Marrow Transplant Program, Kansas City, KS 66103 USA
来源：
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2012年 / 1卷 / 01期
关键词：
autologous; chemotherapy; multiple myeloma; preparative regimen; review; transplant; STEM-CELL TRANSPLANTATION; CONDITIONING REGIMEN; PHASE-II; RANDOMIZED-TRIAL; ALLOGENEIC TRANSPLANTATION; INTERGROUPE FRANCOPHONE; STANDARD CHEMOTHERAPY; 200 MG/M(2); MELPHALAN; CYCLOPHOSPHAMIDE;
D O I：
10.2217/CER.11.11
中图分类号：
R19 [保健组织与事业（卫生事业管理）];
学科分类号：
摘要：
High-dose chemotherapy and autologous stem cell transplantation remains a standard procedure in relatively young and selected older patients with multiple myeloma. High-dose melphalan has remained the chemotherapeutic agent of choice based on earlier prospective randomized trials. Despite investigations involving different combinations of chemotherapeutics, radiation and novel agents with and without melphalan, none of these alternative preparative regimens have demonstrated superiority to high-dose melphalan used as a single agent in multiple published studies. In this article, we review the published literature regarding preparative regimens used in patients with multiple myeloma undergoing autologous stem cell transplantation.
引用
收藏
页码：57 / 70
页数：14
相关论文
共 50 条
  • [21] HIGH-DOSE CHEMOTHERAPY AND AUTOLOGOUS STEM CELL TRANSPLANTATION IN MULTIPLE MYELOMA WITH RENAL FAILURE
    Pokrovskaya, O.
    Mendeleeva, L.
    Urnova, E.
    Firsova, M.
    Nareyko, M.
    Kuzmina, L.
    Rekhtina, I.
    Tauson, I.
    Varlamova, E.
    Parovichnikova, E.
    Savchenko, V.
    BONE MARROW TRANSPLANTATION, 2014, 49 : S345 - S346
  • [22] HIGH-DOSE MELPHALAN WITH AUTOLOGOUS BONE-MARROW TRANSPLANTATION FOR MULTIPLE-MYELOMA
    BARLOGIE, B
    HALL, R
    ZANDER, A
    DICKE, K
    ALEXANIAN, R
    BLOOD, 1986, 67 (05) : 1298 - 1301
  • [23] Multiple myeloma, high-dose treatment and autologous stem cell transplantation - Current status
    Bjorkstrand, B
    MEDICAL ONCOLOGY, 1996, 13 (01) : 23 - 30
  • [24] High-dose chemotherapy with autologous hematopoietic stem cell transplantation in patients with multiple myeloma
    Gertz, Marie A.
    Lacy, Martha Q.
    Dispenzieri, Angela
    Hayman, Suzanne R.
    Kumar, Shaji K.
    EXPERT REVIEW OF ANTICANCER THERAPY, 2006, 6 (03) : 343 - 360
  • [25] Busulfan plus melphalan versus high-dose melphalan as conditioning regimens in autologous stem cell transplantation for newly diagnosed multiple myeloma
    Byun, Ja Min
    Lee, Jayoun
    Shin, Sang-Jin
    Kang, Minjoo
    Yoon, Sung-Soo
    Koh, Youngil
    BLOOD RESEARCH, 2018, 53 (02) : 105 - 109
  • [26] High-Dose Therapy and Autologous Stem Cell Transplantation for Multiple Myeloma: Analysis from Registry of Monoclonal Gammopathy of Czech Myeloma Group
    Hajek, Roman
    Spicka, Ivan
    Maisnar, Vladimir
    Pika, Tomas
    Gregora, Evzen
    Zahradova, Lenka
    Straub, Jan
    Radocha, Jakub
    Minarik, Jiri
    Pavlicek, Petr
    Krejci, Marta
    Pour, Ludek
    Adam, Zdenek
    Scudla, Vlastimil
    BLOOD, 2012, 120 (21)
  • [27] High-dose therapy and autologous stem cell transplant in older adults with multiple myeloma
    T M Wildes
    J D Finney
    M Fiala
    F Gao
    R Vij
    K Stockerl-Goldstein
    K R Carson
    J Mikhael
    G Colditz
    Bone Marrow Transplantation, 2015, 50 : 1075 - 1082
  • [28] High-dose therapy and autologous stem cell transplant in older adults with multiple myeloma
    Wildes, T. M.
    Finney, J. D.
    Fiala, M.
    Gao, F.
    Vij, R.
    Stockerl-Goldstein, K.
    Carson, K. R.
    Mikhael, J.
    Colditz, G.
    BONE MARROW TRANSPLANTATION, 2015, 50 (08) : 1075 - 1082
  • [29] High-dose therapy with peripheral blood progenitor cell transplantation in multiple myeloma
    Goldschmidt, H
    Hegenbart, U
    Wallmeier, M
    Hohaus, S
    Engenhart, R
    Wannenmacher, M
    Haas, R
    ANNALS OF ONCOLOGY, 1997, 8 (03) : 243 - 246
  • [30] Feasibility of high-dose therapy and autologous stem cell transplantation in multiple myeloma patients with severe renal failure.
    Mikhael, JR
    Mazaheri, R
    Sutton, DM
    Stewart, AK
    Chen, CI
    BLOOD, 2001, 98 (11) : 199A - 199A
12345