Pavidolides A-E, new cembranoids from the soft coral Sinularia pavida

被引：34
|
作者：
Shen, Shi [1 ]
Zhu, Huajie [2 ]
Chen, Dawei [1 ]
Liu, Dong [1 ]
van Ofwegen, Leen [3 ]
Proksch, Peter [4 ]
Lin, Wenhan [1 ]
机构：
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
[3] Natl Museum Nat Hist Nat, NL-2300 RA Leiden, Netherlands
[4] Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 43期
关键词：
Soft coral; Sinularia pavida; Pavidolides A-E; Structural elucidation; Antifouling activity; Cytotoxic activity; COELENTERATA; OCTOCORALLIA; CHEMISTRY; DFT;
D O I：
10.1016/j.tetlet.2012.08.049
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Five new cembrane-based diterpenoids, namely pavidolides A-E (1-5) were isolated from the marine soft coral Sinularia pavida, together with sarcophytin and chatancin. The structures of new compounds were determined on the basis of extensive spectroscopic data analysis. Pavidolide B (2) possesses an unprecedented 6,5,7-tricarbocyclic nucleus, whereas pavidolide C (3) is characteristic of an unusual C-5 and C-9 conjuncted cembranoid. Pavidolides C and D showed moderate antifouling activity against the larval settlement of barnacle Balanus amphitrite, while pavidolides B and C exhibited inhibitory activity against the human leukemia cell line HL-60. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5759 / 5762
页数：4
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