In this paper, we construct optimal repeated measurement designs of two treatments for estimating direct effects, and we examine the case of compound symmetry dependency. We present the model and the design that minimizes the variance of the estimated difference of the two treatments. The optimal designs with dependent observations in a compound symmetry model are the same as in the case of independent observations.
机构:
Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USAColumbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA
Zhao, Yihong
Wang, Shuang
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Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USAColumbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA
机构:
Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USAColumbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA
Zhao, Yihong
Wang, Shuang
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机构:
Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USAColumbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA
机构:
Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USAUniv Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA
Wahed, AS
Tsiatis, AA
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机构:Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15261 USA