Design, synthesis and biological activities of Nilotinib derivates as antitumor agents

被引：19
|
作者：
Pan, Xiaoyan [1 ]
Wang, Fang [1 ]
Zhang, Yanmin [1 ]
Gao, Hongping [1 ]
Hu, Zhigang [1 ]
Wang, Sicen [1 ]
Zhang, Jie [1 ]
机构：
[1] Xi An Jiao Tong Univ, Coll Med, Xian 710061, Shaanxi Provinc, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 09期
关键词：
Bcr-Abl; Tyrosine kinase; Leukemia cell; Anticancer; Nilotinib; CHRONIC MYELOGENOUS LEUKEMIA; BCR-ABL; INHIBITORS; DISCOVERY; IMATINIB; AMN107;
D O I：
10.1016/j.bmc.2013.02.036
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A novel class of Nilotinib derivatives, B1-B20, were synthesized in high yields using various substituted anilines. All the title compounds were evaluated for their inhibitory activities against Bcr-Abl and antiproliferative effects on human leukemia cell (K562). The pharmacological results indicated that some compounds exhibited promising anticancer activity. In particular, compound B14 containing tertiary amine side chain exhibited Bcr-Abl inhibitory activity similar to that of Nilotinib. It was suggested that the introduction of the tertiary amine moiety could improve Bcr-Abl inhibitory activity and antitumor effects. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2527 / 2534
页数：8
相关论文
共 50 条
  • [41] Design, synthesis, and biological activity of carbohydrate-linked Smac mimetics as antitumor agents
    Rippin, Susan R.
    LaPorte, Matthew G.
    Deng, Yijun
    Benetatos, Christopher A.
    Chunduru, Srinivas K.
    McKinlay, Mark A.
    Burns, Jennifer M.
    Chou, Jonathan J.
    Hendi, Mukta S.
    Lee, Yu-Hua
    Kumar, Tirunahari P.
    Yu, Guangyao
    Mitsuuchi, Yasuhiro
    Seipel, Martin E.
    Condon, Stephen M.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [42] Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents
    Yiming Xu
    Pengyun Liang
    Haroon ur Rashid
    Lichuan Wu
    Peng Xie
    Haodong Wang
    Shuyan Zhang
    Lisheng Wang
    Jun Jiang
    [J]. Medicinal Chemistry Research, 2019, 28 : 1618 - 1627
  • [43] Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents
    Zi, Cheng-Ting
    Gao, Yin-Sheng
    Yang, Liu
    Feng, Shu-Yun
    Huang, Yue
    Sun, Li
    Jin, Yi
    Xu, Feng-Qing
    Dong, Fa-Wu
    Li, Yan
    Ding, Zhong-Tao
    Zhou, Jun
    Jiang, Zi-Hua
    Yuan, Sheng-Tao
    Hu, Jiang-Miao
    [J]. FRONTIERS IN CHEMISTRY, 2019, 7
  • [44] Design, synthesis, and biological evaluation of quinazoline derivatives containing piperazine moieties as antitumor agents
    Li, Wen
    Chen, Shu-Yi
    Hu, Wei-Nan
    Zhu, Mei
    Liu, Jia-Min
    Fu, Yi-Hong
    Wang, Zhen-Chao
    OuYang, Gui-Ping
    [J]. JOURNAL OF CHEMICAL RESEARCH, 2020, 44 (9-10) : 536 - 542
  • [45] Design, synthesis, and biological evaluation of matrine derivatives possessing piperazine moiety as antitumor agents
    Xu, Yiming
    Liang, Pengyun
    Ur Rashid, Haroon
    Wu, Lichuan
    Xie, Peng
    Wang, Haodong
    Zhang, Shuyan
    Wang, Lisheng
    Jiang, Jun
    [J]. MEDICINAL CHEMISTRY RESEARCH, 2019, 28 (10) : 1618 - 1627
  • [46] Design, Synthesis and Biological Evaluation of Caudatin and its Ester Derivatives as Novel Antitumor Agents
    Tao, Xuefen
    Ma, Yongmin
    Chen, Jing
    Zhao, Huajun
    [J]. NATURAL PRODUCT COMMUNICATIONS, 2015, 10 (04) : 571 - 574
  • [47] Design, synthesis and biological evaluation of naphthalenebenzimidizole platinum (II) complexes as potential antitumor agents
    Liang, Gui-Bin
    Yu, Yan-Cheng
    Wei, Jian-Hua
    Kuang, Wen-Bin
    Chen, Zhen-Feng
    Zhang, Ye
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 188
  • [48] Design, Synthesis and Biological Evaluation of Betulinic Acid Derivatives as New Antitumor Agents for Leukemia
    Waechter, Fernanda
    da Silva, Gloria N. S.
    Willig, Julia B.
    de Oliveira, Cristiane B.
    Vieira, Bruna D.
    Trivella, Daniela B. B.
    Zimmer, Aline R.
    Buffon, Andreia
    Pilger, Diogo A.
    Gnoatto, Simone C. B.
    [J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 17 (13) : 1777 - 1785
  • [49] SYNTHESIS AND ANTITUMOR ACTIVITIES OF TETRACYCLIC QUINOLONE ANTINEOPLASTIC AGENTS
    CHU, DTW
    HALLAS, R
    TANAKA, SK
    ALDER, J
    BALLI, D
    PLATTNER, JJ
    [J]. DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 1994, 20 (05) : 177 - 183
  • [50] Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents
    Abzianidze, Victoria
    Beltyukov, Petr
    Zakharenkova, Sofya
    Moiseeva, Natalia
    Mejia, Jennifer
    Holder, Alvin
    Trishin, Yuri
    Berestetskiy, Alexander
    Kuznetsov, Victor
    [J]. MOLECULES, 2018, 23 (11):
12345