Biological activity of crude extract and saponin pseudoginsenoside-RT1 derived from the fruit of Randia siamensis

被引：7

作者：

Jansakul, C

Intarit, K

Itharat, A

Phadungcharoen, T

Ruangrungsi, N

Merica, A

Lange, GL ^{[1
]}

机构：

[1] Univ Guelph, Guelph Waterloo Ctr Grad Work Chem, Dept Chem & Biochem, Guelph, ON NIG 2W1, Canada

[2] Prince Songkla Univ, Fac Sci, Hat Yai, Thailand

[3] Prince Songkla Univ, Fac Pharmaceut Sci, Hat Yai, Thailand

[4] Chulalongkorn Univ, Fac Pharmaceut Sci, Bangkok, Thailand

来源：

PHARMACEUTICAL BIOLOGY | 1999年 / 37卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

cardiovascular activity; ichthyotoxic activity; pseudoginsenoside-RT1; Randia siamensis; saponins; uterine contractility;

D O I：

10.1076/phbi.37.1.42.6325

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ursolic acid (1) pseudoginsenoside-RP1 (2), and pseudoginsenoside-RT1 (3) were isolated from the fruit of Randia siamensis. C-13 NMR spectroscopy was particularly useful in confirming the structures of these components. Studies with rats showed that saponin 3 caused a decrease in blood pressure, an increase in heart rate and an increase in spontaneous contractility of the uterus. Also, a crude ethanol extract of the fruit of R. siamensis exhibited acute ichthyotoxic activity.

引用

页码：42 / 45

页数：4

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