Rapid diagnosis of tuberculous meningitis by ligase chain reaction amplification

被引：5
|
作者：
Rajo, MC
Del Molino, MLP
Lado, FLL
López, MJ
Prieto, E
Pardo, F
机构：
[1] Hosp Clin Univ Santiago Compostela, Microbiol Serv, Santiago De Compostela 15706, Spain
[2] Hosp Clin Univ Santiago Compostela, Med Interna Serv, Santiago De Compostela 15706, Spain
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2002年 / 34卷 / 01期
关键词：
D O I：
10.1080/00365540110076967
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
A total of 87 cerebrospinal fluid (CSF) samples obtained from 85 patients with suspected meningitis were examined for the presence of Mycobacterium tuberculosis by means of ligase chain reaction amplification (LCx(R); Abbott Laboratories). The results were compared with direct smear and culture results. Of 61 patients with pathological CSF, 9 (14.8%) were scheduled to receive treatment for tuberculous meningitis. The sensitivity of the smear and culture tests was 11.1 and 33.3%, respectively. The sensitivity, specificity, positive predictive value and negative predictive value of the LCx assay were 55.5, 100, 100 and 92.9%, respectively. The results reveal that amplification by ligase chain reaction is valuable for the diagnosis of tuberculous meningitis.
引用
收藏
页码：14 / 16
页数：3
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