Cycloartane-Type Triterpenes from the Leaves of Homonoia riparia with VEGF-Induced Angiogenesis Inhibitory Activity

被引：12
|
作者：
Lee, Iksoo [1 ]
Kim, Junghyun [1 ]
Kim, Young Sook [1 ]
Yoo, Nam Hee [2 ]
Kim, Chan-Sik [1 ]
Jo, Kyuhyung [1 ]
Kim, Joo-Hwan [3 ]
Tran The Bach [4 ]
Kim, Jin Sook [1 ]
机构：
[1] Korea Inst Oriental Med, Herbal Med Res Div, Taejon 305811, South Korea
[2] Int Ginseng & Herb Res Inst, Guemsan 312804, South Korea
[3] Gachon Univ, Dept Life Sci, Songnam 461701, Gyeonggi Do, South Korea
[4] Vietnam Acad Sci & Technol, Inst Ecol & Biol Resources, Dept Bot, Hanoi, Vietnam
来源：
JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 07期
关键词：
ENDOTHELIAL GROWTH-FACTOR; 3,4-SECO-CYCLOARTANE TRITERPENES; GLYCOSIDES;
D O I：
10.1021/np300224k
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Six new cycloartane-type triterpenes (1-6), 24-methylenecydoartane-3 beta,6 beta,7 beta-triol (1), 24-methylenecycloartane-3 beta,6 beta,7 beta,16 beta-tetraol (2), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol (3), 24-methylenecycloartane-3 beta,7 beta,16 beta-triol 3-O-beta-D-xylopyranoside (4), 24-methylenecycloartane-3 beta,6 beta,16 beta-triol 3-O-beta-D-xylopyranoside (5), and 24-methylenecycloartane-3 beta,6 beta,7 beta-triol 3-O-beta-D-xylopyranoside (6), were isolated from the leaves of Homonoia riparia, together with one known compound, 24-methylenecycloartarie-3 beta,6 beta,7 beta,16 beta-tetraol 3-O-beta-D-xylopyranoside (7). The structures of the new triterpenes were established by spectroscopic studies and from chemical evidence, and the inhibitory effects of compounds 1 and 3-7 on VEGF-induced vascular permeability were examined in vivo in rats using the Miles assay. In addition, the inhibitory effect of 7 on VEGF-induced tube formation by HUVECs in vitro was investigated.
引用
收藏
页码：1312 / 1318
页数：7
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