Although Mcl-1 has been established as a survival and maintenance protein during in vitro incubations of primary CLL cells, in this issue of Blood, Pepper and colleagues further demonstrate the association of Mcl-1 with other prognostic factors and the role of this antiapoptotic protein in disease progression and outcome for patients with CLL.
机构:
Univ Southampton, Sch Med, Southampton Gen Hosp, Canc Res UK Oncol Unit, Southampton SO16 6YD, Hants, EnglandUniv Southampton, Sch Med, Southampton Gen Hosp, Canc Res UK Oncol Unit, Southampton SO16 6YD, Hants, England
Michels, J
Johnson, PWM
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机构:
Univ Southampton, Sch Med, Southampton Gen Hosp, Canc Res UK Oncol Unit, Southampton SO16 6YD, Hants, EnglandUniv Southampton, Sch Med, Southampton Gen Hosp, Canc Res UK Oncol Unit, Southampton SO16 6YD, Hants, England
Johnson, PWM
Packham, G
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Univ Southampton, Sch Med, Southampton Gen Hosp, Canc Res UK Oncol Unit, Southampton SO16 6YD, Hants, EnglandUniv Southampton, Sch Med, Southampton Gen Hosp, Canc Res UK Oncol Unit, Southampton SO16 6YD, Hants, England
Packham, G
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,
2005,
37
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