Nickel-Catalyzed Amination of (Hetero)aryl Halides Facilitated by a Catalytic Pyridinium Additive

被引：13

作者：

Han, Dongyang ^{[1
]}

Li, Sasa ^{[1
]}

Xia, Siqi ^{[2
]}

Su, Mincong ^{[2
]}

Jin, Jian ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Chinese Acad Sci, CAS Key Lab Synthet Chem Nat Subst, Ctr Excellence Mol Synth,Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China

[2] Shanghai Univ, Ctr Supramol Chem & Catalysis, Coll Sci, Dept Chem, 99 Shangda Rd, Shanghai 200444, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 54期

基金：

上海市自然科学基金;

关键词：

amination; anilines; aryl halides; C-N coupling; nickel catalysis; COUPLING REACTIONS; ARYL CHLORIDES; PHOTOREDOX; AMINES; PRECATALYST; AMMONIA;

D O I：

10.1002/chem.202002800

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and operationally simple Ni-catalyzed amination protocol has been developed. This methodology features a simple Ni(II)salt, an organic base and catalytic amounts of both a pyridinium additive and Zn metal. A diverse number of (hetero)aryl halides were coupled successfully with primary and secondary alkyl amines, and anilines in good to excellent yields. Similarly, benzophenone imine gave the correspondingN-arylation product in an excellent yield.

引用

页码：12349 / 12354

页数：6

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