The Influence of Gene Conversion on Linkage Disequilibrium Around a Selective Sweep

被引：10
|
作者：
Jones, Danielle A. [1 ]
Wakeley, John [1 ]
机构：
[1] Harvard Univ, Dept Organism & Evolutionary Biol, Cambridge, MA 02138 USA
来源：
GENETICS | 2008年 / 180卷 / 02期
关键词：
D O I：
10.1534/genetics.108.092270
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In a 2007 article, McVean studied the effect of recombination on linkage disequilibrium (LD) between two neutral loci located near a third locus that has undergone a selective sweep. The results demonstrated that two loci on the same side of a selected locus might show substantial LD, whereas the expected LD for two loci on opposite sides of a selected locus is zero. In this article, we extend McVean's model to include gene conversion. We show that one of the conclusions is strongly affected by gene conversion: when gene conversion is present, there may be substantial LD between two loci on opposite sides of a selective sweep.
引用
收藏
页码：1251 / 1259
页数：9
相关论文
共 50 条
  • [41] Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders
    A Serretti
    F Macciardi
    C Cusin
    M Verga
    S Pedrini
    E Smeraldi
    Molecular Psychiatry, 1998, 3 : 169 - 174
  • [42] Tyrosine hydroxylase gene in linkage disequilibrium with mood disorders
    Serretti, A
    Macciardi, F
    Cusin, C
    Verga, M
    Pedrini, S
    Smeraldi, E
    MOLECULAR PSYCHIATRY, 1998, 3 (02) : 169 - 174
  • [43] Refining the Use of Linkage Disequilibrium as a Robust Signature of Selective Sweeps
    Jacobs, Guy S.
    Sluckin, Tim J.
    Kivisild, Toomas
    GENETICS, 2016, 203 (04) : 1807 - +
  • [44] THE ISOLATION OF A GENOMIC CLONE CONTAINING THE APOLIPOPROTEIN CII GENE AND THE DETECTION OF LINKAGE DISEQUILIBRIUM BETWEEN 2 COMMON DNA POLYMORPHISMS AROUND THE GENE
    WALLIS, SC
    DONALD, JA
    FORREST, LA
    WILLIAMSON, R
    HUMPHRIES, SE
    HUMAN GENETICS, 1984, 68 (04) : 286 - 289
  • [45] LINKAGE MAPPING AROUND THE PROC GENE
    KOELEMAN, BPC
    REITSMA, PH
    BERTINA, RM
    CYTOGENETICS AND CELL GENETICS, 1993, 64 (02): : 89 - 89
  • [46] Linkage and linkage disequilibrium analysis of the lipoprotein lipase gene with lipid in Chinese hypertensive families
    Yang, WJ
    Huang, JF
    Yao, CL
    Su, SY
    Liu, DH
    Ge, DL
    Gu, DF
    CLINICAL SCIENCE, 2005, 108 (02) : 137 - 142
  • [47] Extent and distribution of linkage disequilibrium around the SLC11A1 locus
    Yip, SP
    Leung, KH
    Lin, CK
    GENES AND IMMUNITY, 2003, 4 (03) : 212 - 221
  • [48] Extent and distribution of linkage disequilibrium around the SLC11A1 locus
    S P Yip
    K H Leung
    C K Lin
    Genes & Immunity, 2003, 4 : 212 - 221
  • [49] A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees
    Arai, A
    Tanaka, K
    Ikeuchi, T
    Igarashi, S
    Kobayashi, H
    Asaka, T
    Date, H
    Saito, M
    Tanaka, H
    Kawasaki, S
    Uyama, E
    Mizusawa, H
    Fukuhara, N
    Tsuji, S
    ANNALS OF NEUROLOGY, 2002, 52 (04) : 516 - 519
  • [50] LINKAGE DISEQUILIBRIUM IN HUNTINGTONS-DISEASE - AN IMPROVED LOCALIZATION FOR THE GENE
    SNELL, RG
    LAZAROU, LP
    YOUNGMAN, S
    QUARRELL, OWJ
    WASMUTH, JJ
    SHAW, DJ
    HARPER, PS
    JOURNAL OF MEDICAL GENETICS, 1989, 26 (11) : 673 - 675
12345