Difference in BPA uptake between glioma stem-like cells and their cancerous cells

被引：8
|
作者：
Yoshida, Fumiyo [1 ]
Kurita, Tadashi [1 ,2 ]
Endo, Keita [1 ,2 ]
Nakai, Kei [1 ,3 ]
Shirakawa, Makoto [4 ]
Zaboronok, Alexander [1 ]
Tsurubuchi, Takao [1 ]
Ishikawa, Eiichi [1 ]
Matsumura, Akira [1 ]
机构：
[1] Univ Tsukuba, Fac Med, Dept Neurosurg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan
[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan
[3] Ibaraki Prefectural Univ Hlth Sci, 4669-2 Ami, Inashiki, Ibaraki 3000331, Japan
[4] Fukuyama Univ, Dept Pharmaceut Sci, 1 Sanzo,Gakuen Cho, Fukuyama, Hiroshima 7290292, Japan
来源：
APPLIED RADIATION AND ISOTOPES | 2020年 / 164卷 / 164期
基金：
日本学术振兴会;
关键词：
Boron neutron capture therapy; Glioma; Stem cell; Boronophenylalanine; BORONOPHENYLALANINE; COMPLEX;
D O I：
10.1016/j.apradiso.2020.109234
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Tumor sphere-forming (TS) glioma stem cells and cancerous TS cells were analyzed in vivo and in vitro. The boron concentration in murine TS tumors was higher than normal tissue. The boron concentration at 24 h was 0.80 +/- 0.09 mu g/10(7) in the TS cells, and 1.08 +/- 0.08 mu g/10(7) in the cancerous cells. The LAT-1 amino-acid transporter positive rate was 35.4% in the TS cells and 100% in the cancerous cells. These results suggested the relation between LAT-1 expression and boronophenylalanine concentration in vitro.
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页数：5
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