SERUM CALCITRIOL AND INTACT PARATHYROID HORMONE LEVELS IN PATIENTS WITH NON-DIALYSIS CHRONIC KIDNEY DISEASE

Background: Chronic Kidney Disease (CKD) is associated with the processes of mineral and bone disturbance. The process results in secondary hyperparathyroidism leading to vascular calcification associated with increased morbidity and mortality of cardiovascular disease. In mineral and bone disorders, calcium and phosphate balance is disrupted and affect some biomarkers in CKD such as levels of calcitriol and parathyroid hormone. We determined the correlation between the levels of calcitriol and intact parathyroid hormone in patients with non-dialysis CKD. Method: There were 62 CKD patients in Kidney and Hypertension Unit of Dr. Soetomo General Hospital. Patients aged > 18, with no history of dialysis, were included in the study and were willing to participate by signing the informed consent. Serum calcitriol and intact PTH of subjects were measured using the Enzymeimmunoassay (EIA) and Electro-chemiluminescence immunoassay (ECLIA) method, respectively. Results: There were 62 non-dialysis CKD patients consisted of 53 males (85.5%) and 9 females (14.5%). Out of 62, 8 patients had low calcitriol levels and 54 had normal calcitriol levels. The median values of calcitriol were 59.4 pmol/l (45-59 ml/m), 65.2 pmol/l (30-44 ml/m), 66.2 pmol/l (15-29 ml/m), and 60.1 pmol/l (<15 ml/m), while the median values of PTH were 59.3 pg/ml (45-59 ml/m), 56.4 (30-44 ml/m), 92.1 (15-29 ml/m), 162.6 (<15 ml/m), respectively. Spearman correlation test showed no significant correlation between serum calcitriol and intact PTH levels in patients with non-dialysis CKD (p<0.107 and r = -0.207). Conclusion: There was no significant correlation between the levels of serum calcitriol and intact PTH in patients with non-dialysis CKD.