The immune system's involvement in obesity-driven type 2 diabetes

被引：134

作者：

Shu, Chengyi Jenny ^{[1
]}

Benoist, Christophe ^{[1
]}

Mathis, Diane ^{[1
]}

机构：

[1] Harvard Univ, Div Immunol, Dept Microbiol & Immunobiol, Sch Med, Boston, MA 02115 USA

来源：

SEMINARS IN IMMUNOLOGY | 2012年 / 24卷 / 06期

关键词：

Obesity; Type; 2; diabetes; Inflammation; Adipose tissue; Insulin resistance; DIET-INDUCED OBESITY; REGULATORY T-CELLS; ADIPOSE-TISSUE MACROPHAGES; INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; FREE FATTY-ACIDS; B-CELLS; ALTERNATIVE ACTIVATION; NLRP3; INFLAMMASOME; UNIQUE POPULATION;

D O I：

10.1016/j.smim.2012.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：436 / 442

页数：7

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