Histone H2B ubiquitination: the cancer connection

被引：47
|
作者：
Espinosa, Joaquin M. [1 ]
机构：
[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
来源：
GENES & DEVELOPMENT | 2008年 / 22卷 / 20期
关键词：
RNF20; BRE1; H2B ubiquitylation; tumor suppressor; transcription;
D O I：
10.1101/gad.1732108
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Post-translational modifications of histones play a critical role in gene expression control. Ultimately, cancer is a disease of aberrant gene expression. Accordingly, several histone-modifying enzymes have been described as proto-oncogenes or tumor suppressors. Recent reports, including one from Shema and colleagues (pp. 2664 2676) in the October 1, 2008, issue of Genes and Development, indicate that deregulation of histone H2B monoubiquitination may contribute to cancer development.
引用
收藏
页码：2743 / 2749
页数：7
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