Genetic and Environmental Risk Factors for Isolated Hemangiomas in Infants

被引:8
|
作者
Materna-Kiryluk, Anna [1 ]
Wisniewska, Katarzyna [2 ]
Wieckowska, Barbara [3 ]
Wroblewska-Seniuk, Katarzyna [4 ]
Jaroszewska-Swiatek, Beata [5 ]
Helwich, Ewa [6 ]
Latos-Bielenska, Anna [1 ]
机构
[1] Poznan Univ Med Sci, Chair & Dept Med Genet, Polish Registry Congenital Malformat, PL-61701 Poznan, Poland
[2] Poznan Univ Med Sci, Epidemiol Unit, Dept Prevent Med, PL-61701 Poznan, Poland
[3] Poznan Univ Med Sci, Dept Comp Sci & Stat, PL-61701 Poznan, Poland
[4] Poznan Univ Med Sci, Dept Newborns Infect Dis, PL-61701 Poznan, Poland
[5] Univ Warmia & Mazury, Childrens Hosp Olsztyn, Dept Clin Pediat, PL-10651 Olsztyn, Poland
[6] Inst Mother & Child Hlth, Dept Neonatol & Neonatal Intens Care, PL-01211 Warsaw, Poland
来源
CHILDREN-BASEL | 2020年 / 7卷 / 10期
关键词
infant hemangiomas; risk factors; hereditary predisposition; vascular malformations; CLINICAL CHARACTERISTICS; BIRTH; PATHOGENESIS; ESTROGEN; RECEPTOR; HYPOXIA; CARE;
D O I
10.3390/children7100150
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The goal of this analysis is to identify risk factors for infantile hemangiomas (IH) to better delineate hemangioma predisposition. We analyzed live birth children with isolated cutaneous hemangioma that were reported to the Polish Registry of Congenital Malformations from across Poland between the years 1998 and 2016. Lower birthweight and gestational age were the most significant risk factors associated with IH. We also observed a trend for a higher risk of IH with a lower level of maternal and paternal education. Moreover, mothers with IH have a higher probability of having a child with IH compared to fathers. However, this association is only present when the child is female. Similarly, a higher risk of hemangioma in a female child is found among mothers having relatives of the first degree with IH, compared to fathers with a similar pedigree. Our results suggest the role of exogenous factors in the etiology of IH. The analysis of familial cases suggests a multifactorial model of inheritance. The study indicates that female gender is an important risk factor for the expression of familial IH. Potential interaction of genetic risk factors with exposure to female sex hormones may play a role in the development of IH.
引用
收藏
页数:9
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