Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease

被引：22

作者：

Kwon, Young-Man ^{[1
,2
]}

Hwang, Hye Suk ^{[1
,2
]}

Lee, Jong Seok ^{[1
,2
]}

Ko, Eun-Ju ^{[1
,2
]}

Yoo, Si-Eun ^{[1
,2
]}

Kim, Min-Chul ^{[3
]}

Lee, Yu-Na ^{[1
,2
]}

Kim, Ki-Hye ^{[1
,2
]}

Song, Jae-Min ^{[4
]}

Lee, Sujin ^{[5
,6
]}

Moore, Martin L. ^{[5
,6
]}

Kang, Sang-Moo ^{[1
,2
]}

机构：

[1] Georgia State Univ, Ctr Inflammat Immun & Infect, Atlanta, GA 30303 USA

[2] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA

[3] Anim & Plant Quarantine Agcy, Anyang, Gyeonggi Do, South Korea

[4] Sungshin Womens Univ, Dept Global Med Sci, Seoul, South Korea

[5] Emory Univ, Dept Pediat, Atlanta, GA 30322 USA

[6] Childrens Healthcare Atlanta, Atlanta, GA USA

来源：

ANTIVIRAL RESEARCH | 2014年 / 104卷

关键词：

Maternal antibodies; FI-RSV; Passive immunization; Vaccine enhanced disease; PULMONARY INFLAMMATORY RESPONSE; T-CELL RESPONSES; COTTON RATS; RSV VACCINE; G PROTEIN; INFECTION; MICE; PALIVIZUMAB; EOSINOPHILIA; CHALLENGE;

D O I：

10.1016/j.antiviral.2014.01.008

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components. (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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