Some behavioural effects of risperidone in rats: comparison with haloperidol

被引：20
|
作者：
Kowakowska, E
Chodera, A
Kus, K
Rybakowski, J
机构：
[1] Karol Marcinkowski Univ Med Sci, Dept Pharmacol, PL-61701 Poznan, Poland
[2] Karol Marcinkowski Univ Med Sci, Dept Adult Psychiat, PL-61701 Poznan, Poland
来源：
EUROPEAN NEUROPSYCHOPHARMACOLOGY | 1999年 / 9卷 / 05期
关键词：
risperidone; haloperidol; anxiolytic and memory improving effects; forced swimming test;
D O I：
10.1016/S0924-977X(99)00021-8
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Risperidone is a dopaminergic as well as a 5-HT2 antagonist. The drug was found to exert beneficial effects on both positive and negative symptoms of schizophrenia. Since recently, schizophrenia is regarded as a composite of not only positive and negative but also affective and cognitive symptoms, in this study the effects of risperidone compared with typical neuroleptic haloperidol on affective and cognitive functions were investigated in rats (anxiolytic, antidepressive and memory tests). We found, that in contrast to haloperidol risperidone had antidepressive, anxiolytic and memory enhancing effects. The results obtained correspond with favourable effects of risperidone on mood disturbances and cognitive functions of schizophrenic patients observed under clinical conditions. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：421 / 426
页数：6
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