tert-Butoxycarbonyl Chloride for the Introduction of N-Boc Groups into Amino Acids

被引：2
|
作者：
Vorbrueggen, Helmut [1 ,2 ]
机构：
[1] Woodward Res Inst, CH-4000 Basel, Switzerland
[2] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany
来源：
SYNTHESIS-STUTTGART | 2008年 / 23期
关键词：
Boc chloride; COCl2; pyridine; mixed anhydrides; amino acids;
D O I：
10.1055/s-0028-1083227
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
tert-Butoxycarbonyl chloride (BocCI) call be generated in situ from tert-butyl alcohol. COCl2, and pyridine at -74 degrees C to introduce the Boc group in high yield into a hindered amino acid. The method is Suitable for large-scale preparations of Boc-amino acids.
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页码：3739 / 3741
页数：3
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