Quantitative assessment of coronary plaque volume change related to triglyceride glucose index: The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry

被引：49

作者：

Won, Ki-Bum ^{[1
,2
]}

Lee, Byoung Kwon ^{[3
]}

Park, Hyung-Bok ^{[4
,5
]}

Heo, Ran ^{[4
,6
]}

Lee, Sang-Eun ^{[4
,7
]}

Rizvi, Asim ^{[8
,9
,10
]}

Lin, Fay Y. ^{[8
,9
]}

Kumar, Amit ^{[8
,9
]}

Hadamitzky, Martin ^{[11
]}

Kim, Yong-Jin ^{[12
]}

Sung, Ji Min ^{[2
,4
]}

Conte, Edoardo ^{[13
]}

Andreini, Daniele ^{[13
]}

Pontone, Gianluca ^{[13
]}

Budof, Matthew J. ^{[14
]}

Gottlieb, Ilan ^{[15
]}

Chun, Eun Ju ^{[16
]}

Cademartiri, Filippo ^{[17
]}

Mafei, Erica ^{[18
]}

Marques, Hugo ^{[19
]}

Goncalves, Pedro de Araujo ^{[19
]}

Leipsic, Jonathon A. ^{[20
]}

Shin, Sanghoon ^{[7
]}

Choi, Jung Hyun ^{[21
]}

Virmani, Renu ^{[22
]}

Samady, Habib ^{[23
]}

Chinnaiyan, Kavitha ^{[24
]}

Raf, Gilbert L. ^{[24
]}

Stone, Peter H. ^{[25
]}

Berman, Daniel S. ^{[26
]}

Narula, Jagat ^{[27
,28
,29
]}

Shaw, Leslee J. ^{[8
,9
]}

Bax, Jeroen J. ^{[30
]}

Min, James K. ^{[8
,9
]}

Chang, Hyuk-Jae ^{[2
,4
]}

机构：

[1] Univ Ulsan, Coll Med, Dept Cardiol, Ulsan Univ Hosp, Ulsan, South Korea

[2] Yonsei Univ, Yonsei Cedars Sinai Integrat Cardiovasc Imaging R, Severance Cardiovasc Hosp, Dept Cardiol,Coll Med,Yonsei Univ Hlth Syst, 50-1 Yonsei Ro, Seoul 03722, South Korea

[3] Yonsei Univ, Gangnam Severance Hosp, Dept Cardiol, Coll Med, Seoul, South Korea

[4] Yonsei Univ, Yonsei Univ Hlth Syst, Yonsei Cedars Sinai Integrat Cardiovasc Imaging R, Coll Med, Seoul, South Korea

[5] Catholic Kwandong Univ, Dept Cardiol, Int St Marys Hosp, Incheon, South Korea

[6] Hanyang Univ, Seoul Hosp, Dept Cardiol, Coll Med, Seoul, South Korea

[7] Ewha Womans Univ, Dept Cardiol, Med Ctr, Seoul, South Korea

[8] New York Presbyterian Hosp, Dept Radiol, New York, NY USA

[9] Weill Cornell Med Coll, New York, NY USA

[10] Mayo Clin, Dept Radiol, Rochester, MN USA

[11] German Heart Ctr Munich, Dept Radiol & Nucl Med, Munich, Germany

[12] Seoul Natl Univ Hosp, Dept Cardiol, Seoul, South Korea

[13] IRCCS, Ctr Cardiol Monzino, Milan, Italy

[14] Los Angeles Biomed Res Inst, Dept Med, Torrance, CA USA

[15] Casa Saude Sao Jose, Dept Radiol, Rio De Janeiro, Brazil

[16] Seoul Natl Univ, Dept Radiol, Bundang Hosp, Sungnam, South Korea

[17] SDN IRCCS, Cardiovasc Imaging Ctr, Naples, Italy

[18] Area Vasta 1 ASUR, Dept Radiol, Urbino, Italy

[19] Hosp Luz, Unit Cardiovasc Imaging, UNICA, Lisbon, Portugal

[20] Univ British Columbia, Dept Med & Radiol, Vancouver, BC, Canada

[21] Busan Univ Hosp, Dept Cardiol, Busan, South Korea

[22] CVPath Inst, Dept Pathol, Gaithersburg, MD USA

[23] Emory Univ, Sch Med, Dept Cardiol, Atlanta, GA USA

[24] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI 48072 USA

[25] Harvard Med Sch, Brigham & Womens Hosp, Dept Cardiovasc Med, Boston, MA 02115 USA

[26] Cedars Sinai Med Ctr, Dept Imaging & Med, Los Angeles, CA 90048 USA

[27] Icahn Sch Med Mt Sinai, Mt Sinai Heart, New York, NY 10029 USA

[28] Zena & Michael A Wiener Cardiovasc Inst, New York, NY USA

[29] Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, New York, NY USA

[30] Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands

来源：

CARDIOVASCULAR DIABETOLOGY | 2020年 / 19卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Triglyceride glucose index; Coronary artery disease; Atherosclerosis; Coronary computed tomography angiography; HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; CLINICAL-OUTCOMES; SCCT GUIDELINES; ARTERY CALCIUM; CT ANGIOGRAPHY; RISK; IMPACT; HEART;

D O I：

10.1186/s12933-020-01081-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The association between triglyceride glucose (TyG) index and coronary atherosclerotic change remains unclear. We aimed to evaluate the association between TyG index and coronary plaque progression (PP) using serial coronary computed tomography angiography (CCTA). Methods A total of 1143 subjects (aged 60.7 +/- 9.3 years, 54.6% male) who underwent serial CCTA with available data on TyG index and diabetic status were analyzed from The Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography IMaging (PARADIGM) registry. PP was defined as plaque volume (PV) (mm(3)) at follow-up minus PV at index > 0. Annual change of PV (mm(3)/year) was defined as PV change divided by inter-scan period. Rapid PP was defined as the progression of percent atheroma volume (PV divided by vessel volume multiplied by 100) >= 1.0%/year. Results The median inter-scan period was 3.2 (range 2.6-4.4) years. All participants were stratified into three groups based on TyG index tertiles. The overall incidence of PP was 77.3%. Baseline total PV (group I [lowest]: 30.8 (0.0-117.7), group II: 47.2 (6.2-160.4), and group III [highest]: 57.5 (8.4-154.3); P < 0.001) and the annual change of total PV (group I: 5.7 (0.0-20.2), group II: 7.6 (0.5-23.5), and group III: 9.4 (1.4-27.7); P = 0.010) were different among all groups. The risk of PP (odds ratio [OR] 1.648; 95% confidence interval [CI] 1.167-2.327; P = 0.005) and rapid PP (OR 1.777; 95% CI 1.288-2.451; P < 0.001) was increased in group III compared to that in group I. TyG index had a positive and significant association with an increased risk of PP and rapid PP after adjusting for confounding factors. Conclusion TyG index is an independent predictive marker for the progression of coronary atherosclerosis. Clinical registrationClinicalTrials.gov NCT02803411

引用

页数：10

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