Can nanotechnology potentiate photodynamic therapy?

被引:124
|
作者
Huang, Ying-Ying [1 ,2 ,3 ]
Sharma, Sulbha K. [1 ]
Dai, Tianhong [1 ,2 ]
Chung, Hoon [1 ,2 ]
Yaroslavsky, Anastasia [1 ,4 ]
Garcia-Diaz, Maria [1 ,5 ]
Chang, Julie [1 ,6 ]
Chiang, Long Y. [7 ]
Hamblin, Michael R. [1 ,2 ,8 ]
机构
[1] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA
[3] Guangxi Med Univ, Aesthet & Plast Ctr, Nanning, Peoples R China
[4] Boston Univ, Coll Engn, Boston, MA 02215 USA
[5] Univ Ramon Llull, Inst Quim Sarria, Barcelona 08017, Spain
[6] Harvard Univ, Dept Chem, Boston, MA 02115 USA
[7] Univ Massachusetts, Dept Chem, Lowell, MA USA
[8] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
关键词
dendrimer; fullerene; graphene; lipoplex; lipoprotein; liposome; magnetic nanoparticle; micelle; nanocell; nanoparticle; ORMOSIL; polymeric nanoparticle; porphysome; quantum dot; single-walled carbon nanotube; two-photon excitation; upconversion; MESOPOROUS SILICA NANOPARTICLES; WALLED-CARBON-NANOTUBES; DENSITY-LIPOPROTEIN NANOPARTICLES; SINGLET-OXYGEN GENERATION; IRON-OXIDE NANOPARTICLES; SOLUBLE PDT AGENT; IN-VITRO; DRUG-DELIVERY; POLYMERIC MICELLES; TITANIUM-DIOXIDE;
D O I
10.1515/ntrev-2011-0005
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Photodynamic therapy (PDT) uses the combination of nontoxic dyes and harmless visible light to produce reactive oxygen species that can kill cancer cells and infectious microorganisms. Due to the tendency of most photosensitizers (PS) to be poorly soluble and to form nonphotoactive aggregates, drug-delivery vehicles have become of high importance. The nanotechnology revolution has provided many examples of nanoscale drug-delivery platforms that have been applied to PDT. These include liposomes, lipoplexes, nanoemulsions, micelles, polymer nanoparticles (degradable and nondegradable), and silica nanoparticles. In some cases (fullerenes and quantum dots), the actual nanoparticle itself is the PS. Targeting ligands such as antibodies and peptides can be used to increase specificity. Gold and silver nanoparticles can provide plasmonic enhancement of PDT. Two-photon excitation or optical upconversion can be used instead of one-photon excitation to increase tissue penetration at longer wavelengths. Finally, after sections on in vivo studies and nanotoxicology, we attempt to answer the title question, "can nanotechnology potentiate PDT?"
引用
收藏
页码:111 / 146
页数:36
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