Two new isopimarane diterpenoids from the endophytic fungus Xylaria sp SNB-GTC2501

被引：17
|
作者：
Sorres, Jonathan [1 ]
Nirma, Charlotte [1 ]
Toure, Seinde [1 ]
Eparvier, Veronique [1 ]
Stien, Didier [1 ,2 ]
机构：
[1] Univ Paris 11, CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
[2] Univ Paris 04, CNRS, LBBM, Observ Oceanol, F-66650 Banyuls Sur Mer, France
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 31期
关键词：
Xylaria sp; Endophytic fungus; Isopimarane; SECONDARY METABOLITES; DIVERSITY;
D O I：
10.1016/j.tetlet.2015.06.022
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two new isopimarane diterpenoids, xylabisboein A (1) and B (2), as well as three known secondary metabolites (i.e., (-)-5-methylmellein (3), mellein-5-carboxylic acid (4) and ergosterol peroxide (5)), were isolated from a solid culture of the endophytic fungus Xylaria sp. SNB-GTC2501. The structures were elucidated by spectroscopic analysis and the absolute configuration of xylabisboein A (1) was determined by X-ray crystallographic analysis. All of the compounds were tested for their antimicrobial and cytotoxic activities. (C) 2015 Published by Elsevier Ltd.
引用
收藏
页码：4596 / 4598
页数：3
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