Saccharomyces cerevisiae polymerase ζ functions in mitochondria

被引：38
|
作者：
Zhang, HS
Chatterjee, A
Singh, KK
机构：
[1] Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA
[2] Johns Hopkins Oncol Ctr, Baltimore, MD 21231 USA
来源：
GENETICS | 2006年 / 172卷 / 04期
关键词：
D O I：
10.1534/genetics.105.051029
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The MtArg8 reversion assay, which measures point mutation in mtDNA, indicates that in budding yeast Saccharomyces cerevisiae, DNA polymerase zeta and Rev1 proteins participate in the mitochondrial DNA mutagenesis. Supporting this evidence, both polymerase zeta and Rev1p were found to be localized in the mitochondria. This is the first report demonstrating that the DNA polymerase zeta and Rev1 proteins function in the mitochondria.
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页码：2683 / 2688
页数：6
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