A convenient procedure for N-formylation of amines

被引:20
|
作者
Joseph, Sony [1 ]
Das, Prasenjit [1 ]
Srivastava, Bindu [1 ]
Nizar, Hashim [1 ]
Prasad, Mohan [1 ]
机构
[1] Ranbaxy Res Labs, Div Chem Res, Gurgaon 122001, Haryana, India
关键词
N-formylation; Amines; Amino acids; Amino esters; Formamide; Sodium methoxide; Amidation; EFFICIENT;
D O I
10.1016/j.tetlet.2012.12.009
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple and convenient method for the N-formylation of primary and secondary amines including amino acids has been developed utilizing formamide and sodium methoxide in moderate to excellent yield. This reagent is also utilized for one pot conversion of compounds having amino esters to N-formyl amides. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:929 / 931
页数:3
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