Synthesis and design of 2,4-diamino-6-substituted-pyrido[3,2-D]pyrimidines as dihydrofolate reductase inhibitors from opportunistic pathogens.

被引:0
|
作者
Gangjee, A
Ye, ZQ
Kisliuk, RL
Queener, SF
机构
[1] Duquesne Univ, Grad Sch Pharmaceut Sci, Div Med Chem, Pittsburgh, PA 15282 USA
[2] Tufts Univ, Sch Med, Dept Chem, Medford, MA USA
[3] Indiana Univ, Dept Pharmacol & Toxicol, Bloomington, IN USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
353-MEDI
引用
收藏
页码:U172 / U172
页数:1
相关论文
共 50 条
  • [31] 6-substituted 2,4-diaminopyrido[3,2-d]pyrimidine analogues of piritrexim as inhibitors of dihydrofolate reductase from rat liver, Pneumocystis carinii, and Toxoplasma gondii and as antitumor agents
    Gangjee, A
    Zhu, YM
    Queener, SF
    JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (23) : 4533 - 4541
  • [32] The design, synthesis and selective Pneumocystis carinii dihydrofolate reductase inhibitory activities of new 2,4-diamino-5-substituted furo[2,3-d]pyrimidines.
    Gangjee, A
    Guo, X
    Queener, SF
    Cody, V
    CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997, 1997, : 221 - 224
  • [33] Design and synthesis of substituted pyrido[3,2-d]-1,2,3-triazines as potential Pim-1 inhibitors
    Fan, Yin-Bo
    Li, Kun
    Huang, Min
    Cao, Yu
    Li, Ying
    Jin, Shu-Yu
    Liu, Wen-Bing
    Wen, Jia-Chen
    Liu, Dan
    Zhao, Lin-Xiang
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (04) : 1224 - 1228
  • [34] SYNTHESIS OF PYRIDO(2,3-D)- AND -(3,2-D)-SYM-TRIAZOLO(3,4-F)PYRIMIDINES AND OF 4-(1 -PYRAZOLYL)PYRIDO(2,3-D)- AND -(3,2-D)PYRIMIDINES
    GODEFROY, L
    QUEGUINE.G
    PASTOUR, P
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1973, 10 (06) : 1077 - 1078
  • [35] 2,4-DIAMINOPYRIDO[3,2-D]PYRIMIDINE INHIBITORS OF DIHYDROFOLATE-REDUCTASE FROM PNEUMOCYSTIS-CARINII AND TOXOPLASMA-GONDII
    ROSOWSKY, A
    FORSCH, RA
    QUEENER, SF
    JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (14) : 2615 - 2620
  • [36] SYNTHESIS OF PYRIDO [2,3-D] AND [3,2-D] S-TRIAZOLO [3,4-F] PYRIMIDINES AND OF PYRIDO [2,3-D] AND [3,2-D] TETRAZOLO [5,1-F) PYRIMIDINES
    GODEFROY, L
    DECORMEI.A
    QUEGUINE.G
    PASTOUR, P
    COMPTES RENDUS HEBDOMADAIRES DES SEANCES DE L ACADEMIE DES SCIENCES SERIE C, 1974, 278 (24): : 1421 - 1424
  • [37] Design, synthesis and biological evaluation of aryl amino derivatives of pyrido [3,2-d]pyrimidines as anticancer agents
    Syeda, Arshiya Banu
    Syeda, Asra Banu
    Ferazoddin, Mohammad
    Paul, J. P.
    Syed, Tasqeeruddin
    Juluru, Bhasker
    SYNTHETIC COMMUNICATIONS, 2023, 53 (17) : 1426 - 1438
  • [38] 2,4-DIAMINO-5-OXO-6-SUBSTITUTED PYRIDO[2,3-D]PYRIMIDINES AS POTENTIAL NONCLASSICAL ANTIFOLATES
    DEVRAJ, R
    GANGJEE, A
    QUEENER, SF
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 205 : 20 - MEDI
  • [39] 2,4-Diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases
    Gangjee, A
    Vasudevan, A
    Queener, SF
    Kisliuk, RL
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (07) : 1438 - 1446
  • [40] Efficient one-pot synthesis of 2,4-di(het)aryl and 2,4-diamino pyrido[3,2-d]pyrimidines involving regioselective SNAr and palladium-catalyzed reactions
    Tikad, Abdellatif
    Routier, Sylvain
    Akssira, Mohamed
    Guillaumet, Gerald
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2009, 7 (24) : 5113 - 5118