Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil

被引：5

作者：

Pinheiro, Josilene R. ^{[1
,2
]}

dos Reis, Esther C. ^{[1
]}

Farias, Jessica P. ^{[1
]}

Fogaca, Mayanna M. C. ^{[1
]}

da Silva, Patricia de S. ^{[1
,2
]}

Santana, Itana Vivian R. ^{[1
]}

Rocha, Ana Luiza S. ^{[1
]}

Vidal, Paloma O. ^{[1
]}

Simoes, Rafael da C. ^{[1
]}

Luiz, Wilson B. ^{[2
]}

Birbrair, Alexander ^{[3
,4
,5
]}

de Aguiar, Renato S. ^{[6
,7
]}

de Souza, Renan P. ^{[6
]}

Azevedo, Vasco A. de C. ^{[6
]}

Chaves, Gepoliano ^{[8
]}

Belmok, Aline ^{[9
]}

Duraes-Carvalho, Ricardo ^{[10
,11
]}

Melo, Fernando L. ^{[9
]}

Ribeiro, Bergmann M. ^{[9
]}

Amorim, Jaime Henrique ^{[1
,2
]}

机构：

[1] Fed Univ Western Bahia, Ctr Biol Sci & Hlth, BR-47805 Barreiras, BA, Brazil

[2] Univ Estadual Santa Cruz, Dept Biol Sci, BR-45662 Ilheus, BA, Brazil

[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Dermatol, Madison, WI 53706 USA

[4] Univ Fed Minas Gerais, Dept Pathol, BR-31270 Belo Horizonte, MG, Brazil

[5] Columbia Univ, Dept Radiol, Med Ctr, New York, NY 10032 USA

[6] Univ Fed Minas Gerais, Dept Genet Ecol & Evolut, BR-31270 Belo Horizonte, MG, Brazil

[7] DOr Inst Res, BR-22281 Rio De Janeiro, RJ, Brazil

[8] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA

[9] Univ Brasilia, Lab Baculoviruses, BR-70910 Brasilia, DF, Brazil

[10] Fed Univ Sao Paulo UNIFESP, Sao Paulo Sch Med, Dept Microbiol Immunol & Parasitol, BR-04023 Sao Paulo, SP, Brazil

[11] Univ Fed Sao Paulo, Postgrad Program Struct & Funct Biol, BR-04023 Sao Paulo, SP, Brazil

来源：

VIRUSES-BASEL | 2022年 / 14卷 / 10期

基金：

巴西圣保罗研究基金会;

关键词：

COVID-19; impact; variant of concern;

D O I：

10.3390/v14102314

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: The correct understanding of the epidemiological dynamics of COVID-19, caused by the SARS-CoV-2, is essential for formulating public policies of disease containment. Methods: In this study, we constructed a picture of the epidemiological dynamics of COVID-19 in a Brazilian population of almost 17000 patients in 15 months. We specifically studied the fluctuations of COVID-19 cases and deaths due to COVID-19 over time according to host gender, age, viral load, and genetic variants. Results: As the main results, we observed that the numbers of COVID-19 cases and deaths due to COVID-19 fluctuated over time and that men were the most affected by deaths, as well as those of 60 or more years old. We also observed that individuals between 30- and 44-years old were the most affected by COVID-19 cases. In addition, the viral loads in the patients' nasopharynx were higher in the early symptomatic period. We found that early pandemic SARS-CoV-2 lineages were replaced by the variant of concern (VOC) P.1 (Gamma) in the second half of the study period, which led to a significant increase in the number of deaths. Conclusions: The results presented in this study are helpful for future formulations of efficient public policies of COVID-19 containment.

引用

页数：12

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