Pyloricidins, novel anti-Helicobacter pylori antibiotics produced by Bacillus sp.: I.: Taxonomy, fermentation and biological activity

被引：14

作者：

Nakao, M

Miyagawa, K

Nakano, Y

Sakane, T

Tada, M

Nishimura, O

Fujino, M

机构：

[1] Takeda Chem Ind Ltd, Div Pharmaceut Res, Pharmaceut Discovery Ctr, Yodogawa Ku, Osaka 5328686, Japan

[2] Takeda Chem Ind Ltd, Div Pharmaceut Res, Pharmacol Res Labs 2, Yodogawa Ku, Osaka 5328686, Japan

[3] Takeda Chem Ind Ltd, Div Pharmaceut Res, Tsukuba, Ibaraki 3004293, Japan

[4] Takeda Chem Ind Ltd, Chuo Ku, Osaka 5408645, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 11期

关键词：

D O I：

10.7164/antibiotics.54.926

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Novel anti-Helicobacter pylori antibiotics, pyloricidins A, A(1), A(2), B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori infection as a single agent.

引用

页码：926 / 933

页数：8

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