Pd-catalyzed regioselective C-H chlorination of disubstituted 1,2,3-triazoles

被引：5

作者：

Ma, Xinyuan ^{[1
]}

Mo, Qiong ^{[1
]}

Chang, Jie ^{[1
]}

Xie, Kai ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Sci, Jingming South Rd 727, Kunming 650500, Yunnan, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2018年 / 48卷 / 12期

关键词：

1,2,3-Triazole; C-H activation; chlorination; Pd catalyst; DIRECT ARYLATIONS; COUPLING REACTIONS; ARYL CHLORIDES; METAL-FREE; PALLADIUM; CYCLOADDITION; CONSTRUCTION; HALOGENATION; NEGISHI; ACCESS;

D O I：

10.1080/00397911.2018.1455872

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper mainly studied Pd-catalyzed regioselective chlorination of disubstituted 1,2,3-triazoles directed by the 1,2,3-triazole ring. A series of regioselective chlorinated products were synthesized in 47-86% yields using Pd(OAc)(2) as a catalyst and CuCl2 as a chlorinated reagent. This method provides a new mean for the synthesis of 1,2,3-triazole halides which combines the formation of C-X bond with C-H activation. [GRAPHICS] .

引用

页码：1403 / 1412

页数：10

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