Pd-catalyzed ligand-free C(5)-H arylation of 1,4-disubstituted 1,2,3-triazoles promoted by microwaves

被引：6

作者：

Zhao, Fen ^{[1
]}

Tian, Wen-Hai ^{[2
]}

Luo, Fang ^{[1
]}

Cheng, Hui-Ling ^{[1
]}

Jiang, Yu-Bo ^{[1
]}

Chen, Zhen ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Sci, Kunming 650500, Peoples R China

[2] Huaibei Vocat & Tech Coll, Dept Architectural Engn, Huaibei, Peoples R China

来源：

SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 20期

基金：

中国国家自然科学基金;

关键词：

C-H arylation; ligand-free; microwave; Pd-catalyzed; 1,2,3-triazoles; 1,5-DISUBSTITUTED 1,2,3-TRIAZOLES; CLICK CHEMISTRY; 1,4,5-TRISUBSTITUTED 1,2,3-TRIAZOLES; CYCLOADDITION REACTIONS; BIOLOGICAL EVALUATION; ONE-POT; DERIVATIVES; AZIDES; ANTIBACTERIAL; CONSTRUCTION;

D O I：

10.1080/00397911.2016.1222441

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pd(OAc)(2)-catalyzed regioselective C(5)-H arylation of 1,4-disubstituted 1,2,3-triazoles was achieved without ligand under microwave conditions in 1h, generating 1,4,5-trisubstituted 1,2,3-triazoles with good to excellent yields. The obtained molecules can be easily converted into 4,5-disubstituted 1,2,3-triazoles through the debenzylation process with one-pot manipulation. [GRAPHICS] .

引用

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页码：1678 / 1686

页数：9

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