Cytotoxic polyhydroxy serratene triterpenoids from Lycopodium complanatum

被引：10

作者：

Dong, Qiuzhu ^{[1
]}

Zou, Zhenxing ^{[1
]}

Jia, Xiaohui ^{[3
]}

Yu, Xia ^{[1
]}

Li, Jing ^{[1
]}

Zhou, Wenhao ^{[1
]}

Sun, Huihui ^{[1
]}

Wu, Wei ^{[1
]}

Tan, Guishan ^{[1
,2
]}

Xu, Kangping ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[3] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China

来源：

BIOORGANIC CHEMISTRY | 2019年 / 87卷

关键词：

Lycopodium complanatum; Polyhydroxy serratene triterpenoids; Cytotoxic activities; PICEA-JEZOENSIS; A-D; CUTICLE;

D O I：

10.1016/j.bioorg.2019.03.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phytochemical investigation of the 70% aqueous EtOH extract of Lycopodium complanatum led to six new polyhydroxy serratene triterpenoids (serrat A-F, 1-6), along with a known analogue (7). Their structures and configurations were elucidated by data analysis of HRESIMS, 1D and 2D NMR, in combination with comparisons of reported experimental spectroscopic data. All the isolates were evaluated cytotoxic activities against HepG2 cells, MCF-7 cells and series human lung cancer cell lines A549, Calu-6, NCI-H441, NCI-H226 and NCI-H1975. The results indicated that certain compounds inhibited proliferation of human cancer cells. Moreover, all compounds possessed selective cytotoxic activities on MCF-7 cells. Further, possible biosynthesis pathways of these compounds were proposed.

引用

页码：373 / 379

页数：7

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